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| http://dx.doi.org/10.1016/j.asjsur.2023.08.076 | DOI Listing |
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TEX19 increases the levels of CDK4 and promotes breast cancer by disrupting SKP2-mediated CDK4 ubiquitination.
Cancer Cell Int
June 2024
Department of Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, No.44 Xiaoheyan Road, Dadong District, Shenyang, Liaoning Province, 110042, P. R. China.
Background: Globally, breast cancer in women is the fifth leading cause of cancer death. There is an urgent need to explore the molecular mechanism of breast cancer proliferation and metastasis.
Method: TCGA database analysis was used to analyze genes expression in breast cancer and normal samples and the association between gene expression and prognosis.
TEX19 could function as a prognostic biomarker for prostate cancer.
Asian J Surg
December 2023
Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, PR China. Electronic address:
Transcription Factor FOXA1 Facilitates Glycolysis and Proliferation of Lung Adenocarcinoma via Activation of TEX19.
Mol Biotechnol
August 2024
Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua City, 321000, Zhejiang Province, China.
Glycolysis is a shared feature in various cancers including lung adenocarcinoma (LUAD). Testis Expressed 19 (TEX19) is correlated with cancer progression. But its effect on LUAD remains an unanswered question.
View Article and Find Full Text PDFThermal inkjet bioprinting drastically alters cell phenotype.
Biofabrication
May 2023
Biomedical Engineering, The University of Texas at El Paso, El Paso, TX, United States of America.
Article Synopsis
- The text discusses the challenges in quantifying the input and output of inkjet bioprinting of cells since its inception in 2003, highlighting the difficulty in characterizing cells within the printer.
- Recent experiments with adult dermal fibroblasts show positive expression of pluripotency markers and successful cardiomyocyte differentiation post-bioprinting, assessed through immunostaining and RNA sequencing.
- Preliminary results suggest specific gene activation and pathway regulation consistent with pluripotency, revealing both upregulated stem cell markers and expected gene expression changes associated with pluripotent states.
In silico modeling of the interaction between TEX19 and LIRE1, and analysis of TEX19 gene missense SNPs.
Mol Genet Genomic Med
July 2021
Doping Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Background: Testis expressed 19 (TEX19) is a specific human stem cell gene identified as cancer-testis antigen (CTA), which emerged as a potential therapeutic drug target. TEX19.1, a mouse paralog of human TEX19, can interact with LINE-1 retrotransposable element ORF1 protein (LIRE1) and subsequently restrict mobilization of LINE-1 elements in the genome.
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