AI Article Synopsis
- Chronic inflammation keeps the body in a heightened state, linked to diseases like cancer and heart issues, by influencing hematopoietic stem cells (HSCs) to produce proinflammatory cytokines.
- These cytokines can trigger changes in HSC behavior, which are beneficial for fighting off infections but may also contribute to the development of blood-related diseases when HSCs mutate.
- Understanding this intricate relationship is crucial for tracking and managing disease progression, as discussed by experts Dr. Eric Pietras and Dr. Katherine Y. King in a recent webinar.
Article Abstract
Chronic inflammation, although subtle, puts the body in a constant state of alertness and is associated with many diseases, including cancer and cardiovascular diseases. It leads hematopoietic cells to produce and release proinflammatory cytokines, which trigger specific signaling pathways in hematopoietic stem cells (HSCs) that cause changes in proliferation, differentiation, and migration. This response is essential when HSCs are needed to produce specific blood cells to eliminate an intruder, such as a pathogenic virus, but mutant HSCs can use these proinflammatory signals to their advantage and accelerate the development of hematologic disease or malignancy. Understanding this complex process is vital for monitoring and controlling disease progression in patients. In the 2023 International Society for Experimental Hematology winter webinar, Dr. Eric Pietras (University of Colorado Anschutz Medical Campus, United States) and Dr. Katherine Y. King (Baylor College of Medicine, United States) gave a presentation on this topic, which is summarized in this review article.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.exphem.2023.08.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!