The active quickest detection problem with unknown post-change parameters is studied under the sampling control constraint, where there are local streams in a system but one is only able to take observations from one and only one of these local streams at each time instant. The objective is to raise a correct alarm as quickly as possible once the change occurs subject to both false alarm and sampling control constraints. Here we assume that exactly one of the local streams is affected, and the post-change distribution involves unknown parameters. In this context, we propose an efficient greedy-cyclic-sampling-based quickest detection algorithm, and show that our proposed algorithm is asymptotically optimal in the sense of minimizing the detection delay under both false alarm and sampling control constraints. Numerical studies are conducted to show the effectiveness and applicability of the proposed algorithm.
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http://dx.doi.org/10.1080/07474946.2023.2187417 | DOI Listing |
Int J Pharm
January 2025
Drug Product and Device Technologies, BioMarin Pharmaceutical, Inc, Novato, CA 94949, USA.
Glass delamination is a gradual process that may not become apparent until late in storage. Over the past three decades, it has been a leading cause of drug product recalls due to glass particulate contamination. The appearance of glass particles in the solution marks the final stage of glass delamination.
View Article and Find Full Text PDFFront Microbiol
October 2024
Faculty of Engineering and Applied Sciences, Cranfield University, Cranfield, United Kingdom.
BMC Bioinformatics
October 2024
Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Background: The increased interest in research on DNA damage in neurodegeneration has created a need for the development of tools dedicated to the analysis of DNA damage in neurons. Double-stranded breaks (DSBs) are among the most detrimental types of DNA damage and have become a subject of intensive research. DSBs result in DNA damage foci, which are detectable with the marker γH2AX.
View Article and Find Full Text PDFJ Anal Toxicol
October 2024
Office of the Chief Medical Examiner, San Francisco, CA 94124, United States.
One of the quickest-growing subclasses of novel psychoactive substances is novel synthetic opioids (NSOs), which are categorized as fentanyl analogs (fentalogs) or nonfentanyl opioids that bind to the mu-opioid receptor. Increased detections of NSOs have been observed in the USA. However, limited information on their prevalence outside of the East Coast is available.
View Article and Find Full Text PDFPharmaceut Med
July 2024
Biogen, Safety and Benefit Risk Management, Research Triangle Park, NC, USA.
Introduction: Several quantitative methods have been established, in pharmacovigilance, to detect signals of disproportionate reporting (SDRs) from databases containing reports of adverse drug reactions (ADRs). The signal detection algorithms (SDAs) and the source of the reporting per product vary, but it is unclear whether any algorithm can provide satisfactory performance using data with such large variance factors.
Objective: Determine the appropriate SDA for Biogen's internal Global Safety Database (GSD) given the characteristics of the database including frequencies of events, data skewness, outliers, and missing information.
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