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| http://dx.doi.org/10.1093/nsr/nwad215 | DOI Listing |
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Multi-disciplinary research will be the key to stop, restore, and end MS.
Mult Scler
January 2025
Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
The past 25 years have brought extraordinary advances in our understanding of MS pathogenesis and the subsequent development of effective therapies. Collaborative genetics efforts have uncovered the association of 236 common DNA variants with disease susceptibility and the first association with disease severity, paving the way to more effective therapies, particularly for progressive forms of the disease. In parallel, and in addition to established environmental disease triggers or modifiers, new collaborative work has revealed new associations with components of the gut microbiome.
View Article and Find Full Text PDF[Progress on the role of N-end rule pathways in protein degradation].
Sheng Li Xue Bao
December 2024
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325000, China.
The N-end rule pathway is a protein degradation pathway mediated by the ubiquitin-proteasome system, which specifically targets and degrades target proteins by recognizing specific residues at the N-terminus of the proteins. The residues which play a crucial role in the N-end rule pathway are called degrons, also known as N-degrons, as they are usually unstable at the N-terminal end of the protein. Currently, several N-end rule pathways have been identified in the eukaryotes, including the Arg/N-end rule, Ac/N-end rule, and Pro/N-end rule pathways, as well as the recently discovered Gly/N-end rule pathway.
View Article and Find Full Text PDFUnveiling chemical industry secrets: Insights gleaned from scientific literatures that examine internal chemical corporate documents-A scoping review.
PLoS One
January 2025
School of Public Policy and Administration, Carleton University, Ottawa, Canada.
Objective: Examine peer-reviewed scientific articles that used internal industry documents in the chemical sector to reveal corporate influence. Summarize sources of internal documents used in prior scientific papers to identify ongoing corporate strategies within the chemical field. Compare the corporate strategies identified in the chemical sector with the ones identified already identified in the pharmaceutical sector.
View Article and Find Full Text PDFRevealing the secrets of Blue Zones.
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Department of Medical Biochemistry, School of Medicine, Koc University, Istanbul, Türkiye.
Aging is influenced by cellular senescence mechanisms that are associated with oxidative stress. Oxidative stress is the imbalance between antioxidants and free radicals. This imbalance affects enzyme activities and causes mitochondrial dysfunction.
View Article and Find Full Text PDFChromatin accessibility: biological functions, molecular mechanisms and therapeutic application.
Signal Transduct Target Ther
December 2024
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, PR China.
The dynamic regulation of chromatin accessibility is one of the prominent characteristics of eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which is multilevel compressed and access restricted. The remaining accessible loci are generally located in the euchromatin, which have less nucleosome occupancy and higher regulatory activity.
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