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| http://dx.doi.org/10.3389/fmicb.2023.1230234 | DOI Listing |
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RESCUE - Rapid, Effective, Safe Communication in Emergency Departments: A cross-sectional e-survey.
Australas Emerg Care
December 2024
Graduate School of Health, Faculty of Health, University of Technology, Sydney, NSW, Australia.
Background: Effective staff-to-staff and patient-provider communication in the Emergency Department (ED) is essential for safe, quality care. Routine wearing of Personal-Protective-Equipment (PPE) has introduced new challenges to communication. We aimed to understand the perspectives of ED staff about communicating while wearing PPE, and to identify factors contributing to communication success, breakdown, and repair.
View Article and Find Full Text PDFProtein shapeshifting in necroptotic cell death signaling.
Trends Biochem Sci
December 2024
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:
Necroptosis is a mode of programmed cell death executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following its activation by the upstream receptor-interacting protein kinase-3 (RIPK3), subsequent to activation of death, Toll-like, and pathogen receptors. The pathway originates in innate immunity, although interest has surged in therapeutically targeting necroptosis owing to its dysregulation in inflammatory diseases. Here, we explore how protein conformation and higher order assembly of the pathway effectors - Z-DNA-binding protein-1 (ZBP1), RIPK1, RIPK3, and MLKL - can be modulated by post-translational modifications, such as phosphorylation, ubiquitylation, and lipidation, and intermolecular interactions to tune activities and modulate necroptotic signaling flux.
View Article and Find Full Text PDFNeural markers of error processing relate to task performance, but not to substance-related risks and problems and externalizing problems in adolescence and emerging adulthood.
Dev Cogn Neurosci
December 2024
PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway; Center for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Detecting errors and adapting behavior accordingly constitutes an integral aspect of cognition. Previous studies have linked neural correlates of error processing (e.g.
View Article and Find Full Text PDFAssessing hydrogeochemical facies and Groundwater Quality Index in rapidly urbanizing coastal region: a GIS-based approach with machine learning for enhanced management.
Environ Sci Pollut Res Int
December 2024
Department of Earth Sciences, Indian Institute of Technology Roorkee, Roorkee-247667, Roorkee, Uttarakhand, India.
Groundwater is an essential freshwater source worldwide, but increasing pollution poses risks to its sustainability. This study applied a comprehensive approach to assess hydrogeochemical facies and groundwater quality in Odisha's large low-lying coastal regions. Analysis of 136 samples revealed that sodium (9.
View Article and Find Full Text PDFA novel open-source cultivation system helps establish the first full cycle chemosynthetic symbiosis model system involving the giant ciliate .
Front Microbiol
December 2024
Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, United States.
Symbiotic interactions drive species evolution, with nutritional symbioses playing vital roles across ecosystems. Chemosynthetic symbioses are globally distributed and ecologically significant, yet the lack of model systems has hindered research progress. The giant ciliate and its sulfur-oxidizing symbionts represent the only known chemosynthetic symbiosis with a short life span that has been transiently cultivated in the laboratory.
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