Verification and validation (V&V) of systems, and system of systems, in an industrial context has never been as important as today. The recent developments in automated cyber-physical systems, digital twin environments, and Industry 4.0 applications require effective and comprehensive V&V mechanisms. Verification and Validation of Automated Systems' Safety and Security (VALU3S), a Horizon 2020 Electronic Components and Systems for European Leadership Joint Undertaking (ECSEL-JU) project started in May 2020, aims to create and evaluate a multi-domain V&V framework that facilitates evaluation of automated systems from component level to system level, with the aim of reducing the time and effort needed to evaluate these systems. VALU3S focuses on V&V for the requirements of safety, cybersecurity, and privacy (SCP). This paper mainly focuses on the elaboration of one of the 13 use cases of VALU3S to identify the SCP issues in an automated robot inspection cell that is being actively used for the quality control assessment of automotive body-in-white. The joint study here embarks on a collaborative approach that puts the V&V methods and workflows for the robotic arms safety trajectory planning and execution, fault injection techniques, cyber-physical security vulnerability assessment, anomaly detection, and SCP countermeasures required for remote control and inspection. The paper also presents cross-links with ECSEL-JU goals and the current advancements in the market and scientific and technological state-of-play.
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http://dx.doi.org/10.12688/openreseurope.13627.1 | DOI Listing |
PLoS One
January 2025
Intensive Care Unit, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, PR China.
Background: Shenfu injection (SFI), derived from a traditional Chinese medicine (TCM) prescription, is an effective drug for the treatment of sepsis-induced myocardial injury (SIMI) with good efficacy, but its exact therapeutic mechanism remains unclear.
Methods: SwissTargetPrediction and GeneCards database were used to obtain relevant targets for SFI and SIMI. STRING 11.
J Bone Miner Res
January 2025
Department of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, Fukushima-city, Fukushima, Japan.
This study analyzed the association of romosozumab, a human monoclonal antibody with bone-forming and bone resorption-inhibiting effects, and bisphosphonates with the development of cardiovascular disease among patients with osteoporosis. A new-user design was employed to address selection bias, and instrumental variable analysis was used to address confounding by indication. Japanese patients aged ≥40 years, diagnosed with osteoporosis or experienced a fragility fracture, were admitted to medical facilities covered by a commercial administrative claims database, and newly prescribed romosozumab or bisphosphonates after the commercialization of romosozumab in Japan (March 4, 2019) were included based on verification of a 180-day washout period.
View Article and Find Full Text PDFAm J Transl Res
December 2024
Department of Clinical Laboratory, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) Changsha 410002, Hunan, China.
Objective: To develop a nomogram to predict the risk of portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) patients.
Methods: Patients diagnosed with HCC at Hunan Provincial People's Hospital between January 2010 and January 2022 were enrolled. Data on demographic characteristics, comorbidities, and laboratory tests were collected.
Sci China Life Sci
January 2025
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Adipogenesis is the healthy expansion of white adipose tissue (WAT), serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the body. Therefore, the identification of novel regulatory molecules in adipogenesis, specifically membrane receptors such as G protein-coupled receptors (GPCRs), holds significant clinical promise. These receptors can serve as viable targets for pharmaceuticals, offering potential for restoring metabolic homeostasis in individuals with obesity.
View Article and Find Full Text PDFBiomed Chromatogr
February 2025
School of Chinese Medica Materia, Beijing University of Chinese Medicine, Beijing, China.
Panax notoginseng (P. notoginseng) is one of the most famous natural medicines and widely used to promote blood circulation in health care. However, the active component group of P.
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