AI Article Synopsis
- New research suggests that memories can be updated and rewritten during consolidation and reconsolidation when using drugs like beta-adrenergic receptor antagonists, particularly propranolol, which disrupts these processes.
- Propranolol inhibits protein synthesis in the brain, potentially impairing memory during key stages of formation associated with various learning tasks.
- Understanding the effects of propranolol on memory could have significant clinical implications for treating psychological disorders linked to maladaptive memories, such as PTSD, phobias, and addiction.
Article Abstract
Newly acquired memory traces have been thought to become stable and resistant to interruption after they are stored in long-term memory. However, according to a recent research drugs such as beta-adrenergic receptor antagonists enable memories to be updated and rewritten when administered during consolidation and reconsolidation. Propranolol is a widely used beta-adrenergic receptor antagonist that disrupts the consolidation and reconsolidation processes of memory formation as it inhibits protein synthesis in the central nervous system. This review aims to discuss the memory impairing effect of the systemic and intracerebral administration of propranolol during the consolidation and reconsolidation processes associated with different learning tasks. In doing so, this review will help elucidate the effects of propranolol on different stages of memory formation. Since learning and maladaptive memories underpin some of the most common psychological disorders, such as phobias, post-traumatic stress disorder, addiction, drug-seeking behavior, and so on, a thorough understanding of propranolol's memory-impairing effect has significant clinical value and the potential to help people suffering from these disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461772 | PMC |
| http://dx.doi.org/10.29399/npa.28203 | DOI Listing |
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