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http://dx.doi.org/10.1016/j.lana.2023.100573 | DOI Listing |
Small
January 2025
Wuhan National High Magnetic Field Center and School of Physics, Huazhong University of Science and Technology, Wuhan, 430074, China.
Ferroelectric materials, celebrated for their switchable polarization, have undergone significant evolution since their early discovery in Rochelle salt. Initial challenges, including water solubility and brittleness, are overcome with the development of perovskite ferroelectrics, which enable the creation of stable, high-quality thin films suitable for semiconductor applications. As the demand for miniaturization in nanoelectronics has increased, research has shifted toward low-dimensional materials.
View Article and Find Full Text PDFJ Org Chem
January 2025
School of Chemistry, University of Hyderabad, Hyderabad 500 046, Telangana, India.
Aldolases, especially 2-deoxyribose-5-phosphate aldolase (DERA) enzymes, have been widely employed to access key chiral precursors for various active pharmaceutical ingredients (APIs). This has been enabled by expanding their substrate scope toward non-natural acceptors and donors via protein engineering. In this study, we endeavored to broaden the acceptor substrate scope of DERA from sp.
View Article and Find Full Text PDFCureus
December 2024
Trauma and Orthopedics, Lister Hospital, Stevenage, GBR.
Introduction The internet age has broadened the horizons of modern medicine, and the ever-increasing scope of artificial intelligence (AI) has made information about healthcare, common pathologies, and available treatment options much more accessible to the wider population. Patient autonomy relies on clear, accurate, and user-friendly information to give informed consent to an intervention. Our paper aims to outline the quality, readability, and accuracy of readily available information produced by AI relating to common foot and ankle procedures.
View Article and Find Full Text PDFS D Med
September 2024
Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
SGLT2 inhibitors have emerged as a remarkable class of drugs, revolutionizing the management of various medical conditions beyond their initial purpose of controlling diabetes. With their proven benefits in cardiovascular health, kidney disease, hypertension, and even potential applications in cancer treatment, SGLT2 inhibitors have broadened their scope. While concerns about adverse effects and contraindications exist, these medications hold great promise for a diverse range of patients.
View Article and Find Full Text PDFJMIR Res Protoc
January 2025
Health Services Research Centre, Singapore Health Services Pte Ltd, Singapore, Singapore.
Background: Integrating algorithm-based clinical decision support (CDS) systems poses significant challenges in evaluating their actual clinical value. Such CDS systems are traditionally assessed via controlled but resource-intensive clinical trials.
Objective: This paper presents a review protocol for preimplementation in silico evaluation methods to enable broadened impact analysis under simulated environments before clinical trials.
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