AI Article Synopsis
- [18F]AZD4694 is an imaging agent for amyloid beta that has been studied but lacks published longitudinal data on Aβ accumulation.
- A study of 146 participants found that cognitively unimpaired older adults showed slight increases in Aβ accumulation over two years, with greater increases seen in those who were Aβ positive.
- The findings suggest that [18F]AZD4694 could effectively track amyloid levels in both research and clinical contexts, particularly before beginning treatments targeting amyloid.
Article Abstract
Introduction: [18F]AZD4694 is an amyloid beta (Aβ) imaging agent used in several observational studies and clinical trials. However, no studies have yet published data on longitudinal Aβ accumulation measured with [18F]AZD4694.
Methods: We assessed 146 individuals who were evaluated with [18F]AZD4694 at baseline and 2-year follow-up. We calculated annual rates of [18F]AZD4694 change for clinically defined and biomarker-defined groups.
Results: Cognitively unimpaired (CU) older adults displayed subtle [18F]AZD4694 standardized uptake value ratio (SUVR) accumulation over the follow-up period. In contrast, Aβ positive CU older adults displayed higher annual [18F]AZD4694 SUVR increases. [18F]AZD4694 SUVR accumulation in Aβ positive mild cognitive impairment (MCI) and dementia was modest across the neocortex.
Discussion: Larger increases in [18F]AZD4694 SUVR were observed in CU individuals who had abnormal amyloid positron emission tomography levels at baseline. [18F]AZD4694 can be used to monitor Aβ levels in therapeutic trials as well as clinical settings, particularly prior to initiating anti-amyloid therapies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461075 | PMC |
| http://dx.doi.org/10.1002/dad2.12391 | DOI Listing |
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