Monopoles and vortices are fundamental topological excitations that appear in physical systems spanning enormous scales of size and energy, from the vastness of the early universe to tiny laboratory droplets of nematic liquid crystals and ultracold gases. Although the topologies of vortices and monopoles are distinct from one another, under certain circumstances a monopole can spontaneously and continuously deform into a vortex ring with the curious property that monopoles passing through it are converted into anti-monopoles. However, the observation of such Alice rings has remained a major challenge, due to the scarcity of experimentally accessible monopoles in continuous fields. Here, we present experimental evidence of an Alice ring resulting from the decay of a topological monopole defect in a dilute gaseous Rb Bose-Einstein condensate. Our results, in agreement with detailed first-principles simulations, provide an unprecedented opportunity to explore the unique features of a composite excitation that combines the topological features of both a monopole and a vortex ring.
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http://dx.doi.org/10.1038/s41467-023-40710-2 | DOI Listing |
Cereb Cortex
January 2025
Aging Research Center, Karolinska Institutet and Stockholm University, Tomtebodavägen 18 A, SE-171 65 Solna, Sweden.
Although age differences in the dopamine system have been suggested to contribute to age-related cognitive decline based on cross-sectional data, recent large-scale cross-sectional studies reported only weak evidence for a correlation among aging, dopamine receptor availability, and cognition. Regardless, longitudinal data remain essential to make robust statements about dopamine losses as a basis for cognitive aging. We present correlations between changes in D2/3 dopamine receptor availability and changes in working memory measured over 5 yr in healthy, older adults (n = 128, ages 64 to 68 yr at baseline).
View Article and Find Full Text PDFFEBS J
January 2025
Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Sweden.
Mucus in the colon is crucial for intestinal homeostasis by forming a barrier that separates microbes from the epithelium. This is achieved by the structural arrangement of the major mucus proteins, such as MUC2 and FCGBP, both of which are comprised of several von Willebrand D domains (vWD) and assemblies. Numerous disulfide bonds stabilise these domains, and intermolecular bonds generate multimers of MUC2.
View Article and Find Full Text PDFClin Biomech (Bristol)
December 2024
Facultad de Enfermería y Podología, Universidad de Valencia, C/Jaume Roig s/n, 46010, Valencia, Spain. Electronic address:
Background: Normal dorsiflexion of the first metatarsophalangeal joint during dynamic activities is critical for effective propulsion. Therapeutic foot orthotics may address the pathomechanical loading and joint kinematics issues faced by this population. This study aims to evaluate the effect of two different types of Custom-made foot orthosis compared to shod condition on the stiffness of the rearfoot, midfoot, and 1st metatarsophalangeal joint during walking in patients with Structural Hallux Limitus.
View Article and Find Full Text PDFJAMA Netw Open
December 2024
Nethersole Institute of Continuing Holistic Health Education (NICHE), Alice Ho Miu Ling Nethersole Charity Foundation, Hong Kong, China.
Importance: Domiciliary noninvasive ventilation (NIV) is a standard treatment for improving health outcomes among patients with chronic hypercapnic respiratory failure (CHRF). However, poor adherence substantially limits its therapeutic effectiveness.
Objective: To determine the effect of an information-motivation-behavioral (IMB) skills-based intervention (IMB-NIV program) on NIV adherence, patient-reported health outcomes, and health service use among patients with CHRF.
Background: The aim of the study was to investigate the development of evidence-based monitoring strategies in a population with progressive or recurrent disease. A simulation study of monitoring strategies using a new biomarker (ELF) for the detection of liver cirrhosis in people with known liver fibrosis was undertaken alongside a randomised controlled trial (ELUCIDATE).
Methods: Existing data and expert opinion were used to estimate the progression of disease and the performance of repeat testing with ELF.
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