AI Article Synopsis

  • A national study in Scotland examined how SARS-CoV-2 infection and COVID-19 vaccination during pregnancy affect maternal and neonatal health outcomes in women with singleton pregnancies lasting 20 weeks or longer.
  • Results showed that SARS-CoV-2 infection is linked to higher risks of preterm births, severe maternal complications, and venous thromboembolism.
  • Conversely, the study found no increased risks associated with COVID-19 vaccination, indicating it is a safe choice for pregnant women to help protect themselves and their babies.

Article Abstract

Understanding the impact of SARS-CoV-2 infection and COVID-19 vaccination in pregnancy on neonatal and maternal outcomes informs clinical decision-making. Here we report a national, population-based, matched cohort study to investigate associations between SARS-CoV-2 infection and, separately, COVID-19 vaccination just before or during pregnancy and the risk of adverse neonatal and maternal outcomes among women in Scotland with a singleton pregnancy ending at ≥20 weeks gestation. Neonatal outcomes are stillbirth, neonatal death, extended perinatal mortality, preterm birth (overall, spontaneous, and provider-initiated), small-for-gestational age, and low Apgar score. Maternal outcomes are admission to critical care or death, venous thromboembolism, hypertensive disorders of pregnancy, and pregnancy-related bleeding. We use conditional logistic regression to derive odds ratios adjusted for socio-demographic and clinical characteristics (aORs). We find that infection is associated with an increased risk of preterm (aOR=1.36, 95% Confidence Interval [CI] = 1.16-1.59) and very preterm birth (aOR = 1.90, 95% CI 1.20-3.02), maternal admission to critical care or death (aOR=1.72, 95% CI = 1.39-2.12), and venous thromboembolism (aOR = 2.53, 95% CI = 1.47-4.35). We find no evidence of increased risk for any of our outcomes following vaccination. These data suggest SARS-CoV-2 infection during pregnancy is associated with adverse neonatal and maternal outcomes, and COVID-19 vaccination remains a safe way for pregnant women to protect themselves and their babies against infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465539PMC
http://dx.doi.org/10.1038/s41467-023-40965-9DOI Listing

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