AI Article Synopsis
- Statins are effective in preventing cardiovascular disease but raise concerns due to their potential to cause diabetes.
- The exact mechanism behind this diabetogenic effect of statins is not well understood.
- This text proposes that statins might cause an accumulation of acetate, which could inhibit insulin secretion by stimulating specific receptors (FFA2 and FFA3).
Article Abstract
Despite the proven effects of statins in preventing cardiovascular disease, their diabetogenic effect has caused concern. The mechanism of this diabetogenic effect is unknown. We suggest a novel mechanism that may contribute to the diabetogenic effect of statins, through an effect of statins that has apparently escaped previous consideration. Briefly, by inhibiting HMG-CoA reductase, statins may cause accumulation of acetate, which through FFA2 and FFA3 stimulation may inhibit insulin secretion.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791749 | PMC |
| http://dx.doi.org/10.1007/s00210-023-02647-7 | DOI Listing |
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