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Rediscovery of the Endangered Pseudophilotes fatma (Oberthür, 1890) (Lepidoptera: Lycaenidae) in Algeria after 71 years, with an update on its distribution and designation of a lectotype.
Zootaxa
December 2024
Algerian Wildlife Watchers Association; Cité El-Hay; BT 53; nº 8; Hassi Bahbah 17002; Djelfa; Algeria.
Pseudophilotes fatma (Oberthür, 1890) is a Palearctic butterfly species endemic to the Maghreb region, characterised by a highly restricted distribution and "Endangered" conservation status. Recent field observations in Batna Province, northeastern Algeria, have documented new localities for P. fatma, marking its rediscovery after a 71-year absence.
View Article and Find Full Text PDFStress granules formation in HEI-OC1 auditory cells and in H4 human neuroglioma cells secondary to cisplatin exposure.
Cell Stress
October 2024
University Medical Center Göttingen, Department of Otolaryngology-Head and Neck Surgery, InnerEarLab Göttingen Germany.
Stress granules (SGs) are highly dynamic micromolecular membraneless condensates that generate in cells subjected to stress. Formed from pools of untranslating messenger ribonucleoproteins (RNP), SGs dynamics constitute vital processes essential for cell survival. Here, we investigate whether established cytotoxic agents, such as the platinum-based chemotherapeutic agent cisplatin and the aminoglycoside antibiotic gentamicin, elicit SG formation in the House Ear Institute-Organ of Corti-1 (HEI-OC1) auditory cell line, H4 human neuroglioma cells and HEK-293T human embryonic kidney cells.
View Article and Find Full Text PDFLocking plate fixation in comminuted coronoid fractures with partial loss of the articular cartilage - Of basal-1 type according to the O'Driscoll classification.
Injury
June 2024
Department of Orthopedic Surgery, Regional Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.
Background: We have attempted to restore the arc of motion by considering trochlear-coronoid articulation as a complete circle during fixation of the coronoid, even for comminuted coronoid fractures with partial loss of articular cartilage (CCFPLAC), using various kinds of locking plates. Herein, we report the radiological and clinical outcomes after fixation of the basal-1 type of CCFPLAC (O'Driscoll classification) using our method.
Methods: Thirty-one patients diagnosed with CCFPLAC were admitted between January 2012 and December 2020.
Cinpanemab in Early Parkinson Disease: Evaluation of Biomarker Results From the Phase 2 SPARK Clinical Trial.
Neurology
March 2024
From Biogen Inc. (R.M.H., K.F., M.Y., E.H., K.C.E., D.G., L.M., J.B.), Cambridge, MA; Biogen Inc. (T.F.), Maidenhead, United Kingdom; Formerly Biogen Inc. at time of study (E.N., J.M.C., T.D.); Clario (D.S.), Princeton, NJ; Biospective Inc. (B.J.B.), Montreal, Quebec, Canada; Nucleus Global (K.M.K.), Atlanta, GA; Coeruleus Clinical Sciences LLC (J.M.C.), Woodbridge, CT; Department of Neurology (B.M.), University Medical Center, Göttingen and Paracelsus-Elena-Klinik, Kassel, and Scientific Employee with an Honorary Contract at German Center for Neurodegenerative Diseases (DZNE), Germany; Morton and Gloria Shulman Movement Disorders Clinic (A.E.L.); and Edmond J. Safra Program in Parkinson's Disease (A.E.L.), Toronto, Ontario, Canada.
Background And Objectives: Sensitive, reliable, and scalable biomarkers are needed to accelerate the development of therapies for Parkinson disease (PD). In this study, we evaluate the biomarkers of early PD diagnosis, disease progression, and treatment effect collected in the SPARK.
Methods: Cinpanemab is a human-derived monoclonal antibody binding preferentially to aggregated forms of extracellular α-synuclein.
Correction to Notes on the Melitaea ornata Christoph, 1893, complex in the Levant (Lepidoptera: Nymphalidae) including new synonymy and observations on lectotype designations for Melitaea phoebe dorae Graves, 1925.
Zootaxa
November 2023
Scientific Associate; Department of Life Sciences; Natural History Museum London SW7 5BD; UK; Honorary Associate; Oxford Museum of Natural History; Parks Road; Oxford OX1 3PW; UK.
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