AI Article Synopsis
- Chromatin structure changes are crucial during oocyte growth and zygote development, influencing nuclear activities.
- The study highlights the importance of SMC2, a key protein in the condensin complex, for female fertility, revealing that its absence leads to infertility despite normal oocyte maturation.
- Without SMC2, there are defects in chromosome condensation, DNA damage, disorganized pronuclei, and halted embryo development at the one-cell stage, indicating its critical role in embryonic development.
Article Abstract
During the oocyte growth, maturation and zygote development, chromatin structure keeps changing to regulate different nuclear activities. Here, we reported the role of SMC2, a core component of condensin complex, in oocyte and embryo development. Oocyte-specific conditional knockout of SMC2 caused female infertility. In the absence of SMC2, oocyte meiotic maturation and ovulation occurred normally, but chromosome condensation showed defects and DNA damages were accumulated in oocytes. The pronuclei were abnormally organized and micronuclei were frequently observed in fertilized eggs, their activity was impaired, and embryo development was arrested at the one-cell stage, suggesting that maternal SMC2 is essential for embryonic development.
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| http://dx.doi.org/10.1002/jcp.31102 | DOI Listing |
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