Tamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, antiinflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1976 to 2023 are obtained from PubMed, China Knowledge Base Database, Wanfang Data, and other electronic databases. Tamarixetin is searched based on keywords, and 121 articles remain. Transformation synthesis, pharmacokinetics, pharmacological action, and structureactivity relationship of tamarixetin were reviewed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1389557523666230828123425 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Five New Tamarixetin Glycosides from Griseb. Including Some Substituted with the Rare 3-Hydroxy-3-methylglutaric Acid and Their Collagenase Inhibitory Effects In Vitro.
ACS Omega
April 2024
Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Palackého tř. 1946/1, Brno 61200, Czech Republic.
Along with the known kaempferol-3--α-l-rhamnopyranosyl-(1 → 2)-[6--(3-hydroxy-3-methylglutaryl)]-β-d-galactopyranoside (), five new flavonoids, containing the rarely isolated aglycon tamarixetin, were isolated from a methanolic extract of the endemic Balkan species Griseb. Three of the new compounds are substituted with 3-hydroxy-3-methylglutaryl residue (HMG), untypical for the genus . The compounds were identified as tamarixetin-3--α-l-rhamnopyranosyl-(1 → 2)-[6--(3-hydroxy-3-methylglutaryl)]-β-d-galactopyranoside (), tamarixetin-3--(2,6-di--α-l-rhamnopyranosyl)-β-d-galactopyranoside (), tamarixetin 3--β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside (), tamarixetin-3--β-d-apiofuranosyl-(1 → 2)-[6--(3-hydroxy-3-methylglutaryl)]-β-d-galactopyranoside (), and tamarixetin-3--β-d-apiofuranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 6)]-β-d-galactopyranoside ().
View Article and Find Full Text PDFQuercetin Derivatives as Potential Therapeutic Agents: An Updated Perspective on the Treatment of Nicotine-Induced Non-Small Cell Lung Cancer.
Int J Mol Sci
October 2023
Heart, Mind and Body Research Group, Griffith University, Gold Coast, QLD 4222, Australia.
Flavonoids are the largest group of polyphenols, represented by many compounds that exhibit high anticancer properties. Quercetin (Q) and its main derivatives (rutin, quercitrin, isoquercitrin, isorhamnetin, tamarixetin, rhamnetin, and hyperoside) in the class of flavonols have been documented to exert anticancer activity. Q has been shown to be useful in the treatment of non-small cell lung cancer (NSCLC), as demonstrated by in vitro/in vivo studies, due to its antitumor, anti-inflammatory, anti-proliferative, anti-angiogenesis, and apoptotic properties.
View Article and Find Full Text PDFResearch Progress of Tamarixetin and its Glycosides.
Mini Rev Med Chem
May 2024
School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Tamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, antiinflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis.
View Article and Find Full Text PDFCharacterization Variation of the Differential Coloring Substances in Rapeseed Petals with Different Colors Using UPLC-HESI-MS/MS.
Molecules
July 2023
Shaanxi Province Key Laboratory of Bio-Resources, Qinba Mountain Area Collaborative Innovation Center of Bioresources Comprehensive Development, Qinba State Key Laboratory of Biological Resources and Ecological Environment (Incubation), School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723001, China.
Rapeseed's ( L.) colorful petals have important ornamental values. However, the mechanisms of regulating petals coloration in rapeseed are still unknown.
View Article and Find Full Text PDFTwo New Phenolic Glycosides with Lactone Structural Units from Leaves of Sims with Antibacterial and Anti-Inflammatory Activities.
Molecules
July 2022
College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Two new lactones, named Ardisicreolides A-B (-), together with four known flavonoids, Quercetin (), Myricetrin (), Quercitrin (), Tamarixetin 3-O-rhamnoside (), were isolated from the ethyl acetate portion of 70% ethanol extracts of dried leaves from Sims. These compounds were identified from Sims for the first time. The structures of - were elucidated according to 1D and 2D-NMR methods and together with the published literature.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!