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Encapsulation, vacuolation, and phagocytosis of the opportunistic fungal pathogen Cryptococcus in the liver of an immunocompetent host.
Microscopy (Oxf)
January 2025
Department of Forest Ecology and Protection, Kyungpook National University, Sangju 37224, Republic of Korea.
The cellular characteristics of the opportunistic fungal pathogen Cryptococcus species were investigated in the infected liver of an immunocompetent host using transmission electron microscopy (TEM). With no records of immunodeficiency, the 3-year-old female patient displayed a high-grade fever, lethargy, and increasing jaundice. TEM analysis revealed the presence of round yeast cells in the patient's liver.
View Article and Find Full Text PDFCargo hitchhiking autophagy - a hybrid autophagy pathway utilized in yeast.
Autophagy
January 2025
Department of Cell and Molecular Biology, Virtua Health College of Medicine and Life Sciences, School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.
Macroautophagy is a catabolic process that maintains cellular homeostasis by recycling intracellular material through the use of double-membrane vesicles called autophagosomes. In turn, autophagosomes fuse with vacuoles (in yeast and plants) or lysosomes (in metazoans), where resident hydrolases degrade the cargo. Given the conservation of autophagy, is a valuable model organism for deciphering molecular details that define macroautophagy pathways.
View Article and Find Full Text PDFESCRT elicits vacuolar fission in the absence of Vps4 in budding yeast.
Biochem Biophys Res Commun
December 2024
Graduate School of Science and Technology, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan; Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan. Electronic address:
In budding yeast, endosomal sorting complex required for transport (ESCRT) mediates microautophagy by vacuolar membrane invagination into the vacuolar lumen, followed by Vps4-assisted membrane constriction and abscission. Here, we show that ESCRT elicits vacuolar fission in the absence of Vps4 after nutrient starvation, although vacuolar fusion is facilitated in wild-type cells in these conditions. ESCRT mediated vacuolar membrane invagination in vps4Δ cells, thereby causing vacuolar fission.
View Article and Find Full Text PDF5-Aminolevulinic acid improves strawberry salt tolerance through a NO-HO signaling circuit regulated by FaWRKY70 and FaWRKY40.
J Adv Res
December 2024
College of Horticulture, Nanjing Agricultural University, Nanjing 21095, China. Electronic address:
Introduction: 5-Aminolevulinic acid (ALA) is an essential biosynthetic precursor of tetrapyrrole compounds, naturally occurring in all living organisms. It has also been suggested as a new plant growth regulator. Treatment with ALA promotes strawberry Na homeostasis under salt stress.
View Article and Find Full Text PDFReV as a Novel S. cerevisiae-Derived Drug Carrier to Enhance Anticancer Therapy through Daunorubicin Delivery.
Appl Biochem Biotechnol
December 2024
Graduate School of Semiconductor and Chemical Engineering, Jeonbuk National University, 567 Baekje-Daero, Deokjin-Gu Jeonju, Jeonbuk, 54896, South Korea.
This study explores the potential of vacuoles derived from Saccharomyces cerevisiae (S. cerevisiae) as a novel form of drug carrier, specifically focusing on their application in enhancing the delivery of the chemotherapeutic agent Daunorubicin (DNR). We isolated and reassembled these vacuoles, referred to as Reassembled Vacuoles (ReV), aiming to overcome the challenges of drug degradation caused by hydrolytic enzymes within traditional vacuoles.
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