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Edaravone Mitigates Hippocampal Neuronal Death and Cognitive Dysfunction by Upregulating BDNF Expression in Neonatal Hypoxic-Ischemic Rats.
Int J Dev Neurosci
February 2025
Department of Digestive and Nutrition, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Neonatal hypoxic-ischemic encephalopathy (HIE) is a severe neurological injury during infancy, often resulting in long-term cognitive deficits. This study aimed to investigate the neuroprotective effects of Edaravone (EDA), a free radical scavenger, and elucidate the potential role of brain-derived neurotrophic factor (BDNF) in mediating these effects in neonatal HIE rats. Using the Rice-Vannucci model, HIE was induced in neonatal rats, followed by immediate administration of EDA after the hypoxic-ischemic insult.
View Article and Find Full Text PDFUtilizing preterm infant body composition assessments to guide neonatal nutrition.
Curr Opin Pediatr
January 2025
Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.
Purpose Of Review: The use of body composition to assess the quality of infant growth may add valuable information to pediatric clinical care. Preterm infants have differences in their fat and muscle mass development compared with infants born at term, which may be related to their early nutritional exposures. This review focuses on recent studies examining early nutrition in preterm infants and related body composition outcomes in the newborn period and beyond.
View Article and Find Full Text PDFStreptococcus canis Rapidly Progressive and Fatal Neonatal Sepsis in a Term Infant.
Pediatr Infect Dis J
January 2025
From the Division of Pediatric Infectious Diseases.
Background: Streptococcus canis (S. canis), belonging to β-hemolytic group G streptococci, is increasingly reported to cause sepsis and severe infections in adults with comorbidities but is rarely reported in children.
Methods: We describe a case of S.
Subpial hemorrhage: A rare and underrecognized site of intracranial hemorrhage in neonates.
Radiol Case Rep
March 2025
From the Department of Radiology, University of Bourgogne Franche-Comté, CHRU Besançon, 3 boulevard Alexandre Fleming, Besançon 25030, France.
Subpial hemorrhage (SPH) is a rare but significant cause of neonatal seizures and respiratory distress, primarily affecting full-term infants without apparent risk factors. We report the case of a full-term newborn who presented with recurrent episodes of apnea, desaturation, and seizures shortly after birth. MRI revealed an acute hemorrhagic collection in the left temporal region, accompanied by cortical cytotoxic edema.
View Article and Find Full Text PDFTrim the sail: A rare cause of newborn hypoxia.
Ann Pediatr Cardiol
December 2024
Department of Pediatrics, Division of Neonatology, University of Illinois College of Medicine - Peoria, Peoria, IL, USA.
The right venous valve is critical to the proper development of the fetal heart. As the right venous valve degenerates later in fetal development, residual structures can remain, such as the terminal crest, Eustachian valve, Thebesian valve, and a prominent Chiari network, with a sail-like appearance resembling a spinnaker. While these structures are often incidentally found on adult echocardiograms, we present a case of a term neonate with hypoxia secondary to a persistent right valve of the sinus venosus.
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