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http://dx.doi.org/10.1016/j.jclinane.2023.111239 | DOI Listing |
J Exp Bot
January 2025
Department of Plant Ecophysiology, Faculty of Biology, Adam Mickiewicz University; Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.
Through extensive research, nitroxyl (HNO) has emerged as a newly recognized redox signal in plant developmental and stress responses. The interplay between nitric oxide (●NO) and HNO entails a complex network of signaling molecules and regulatory elements sensitive to the environment's specific redox conditions. However, functional implications for HNO in cell signaling require more detailed studies, starting with identifying HNO-level switches.
View Article and Find Full Text PDFQJM
December 2024
Assistant Professor, All India Institute of Medical Sciences, Delhi, 110029, India.
Prog Neuropsychopharmacol Biol Psychiatry
November 2024
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:
Objective: The relationship between the duration of untreated psychosis (DUP) and cognitive function in schizophrenia (SZ) patients remains debated, with no empirical evidence from event-related potential (ERP) studies supporting their association. This study aims to investigate the relationship between DUP and cognitive functions, as well as psychiatric symptoms, in first-episode antipsychotic-naïve SZ (FEAN-SZ) patients using ERP.
Methods: The study included 321 Chinese FEAN-SZ patients and 146 healthy controls.
Circulation
December 2024
British Heart Foundation Cardiovascular Research Centre, University of Glasgow, United Kingdom (L.S., P.D., P.S.J., J.J.V.M.).
Background: Cognitive impairment is common in patients with heart failure and preserved ejection fraction but its clinical correlates and prognostic associations are poorly understood.
Methods: We analyzed cognitive function, using the Mini-Mental State Examination (MMSE), in patients with heart failure and preserved ejection fraction enrolled in a prespecified substudy of the PARAGON-HF trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin Receptor Blocker Global Outcomes in Heart Failure With Preserved Ejection Fraction). Logistic regression analyses were performed to determine the variables associated with lower MMSE scores at baseline and postbaseline decline in MMSE scores at 48 weeks.
Br J Psychiatry
October 2024
Chair of E.P.S.I.G., Royal College of Psychiatrists, London, UK.
The biopsychosocial model remains a key paradigm for healthcare, despite widely recognised scientific and philosophical shortcomings. Here we report on recent updates integrating evolutionary theory with the biopsychosocial model to provide a more comprehensive and scientifically complete approach to understanding the multiple relevant levels of causation of medical and psychiatric problems.
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