AI Article Synopsis
- Potassium channels are essential for regulating cell volume, and a new sensor was developed to study their function during regulatory volume decrease (RVD).
- The sensor effectively monitored K channel activity noninvasively, showing that calcium activation increases RVD levels.
- Differences in RVD levels between normal and cancerous nasopharyngeal cells reveal that K channels play a significant role in RVD and can help identify various K channel activations.
Article Abstract
Potassium channels play a vital role in cell volume regulation. A cell volume sensor was constructed by integrating regulatory volume decrease (RVD) with quartz-crystal microbalance (QCM) for studying potassium channels and their expression. The sensor successfully monitored the K channel's activities during RVD by sensitive and noninvasive means. It showed that Ca activated the K channel (K) and enhanced the RVD level. The inhibition of blockers on K channels exhibited an obvious difference in RVD level between normal and cancerous nasopharyngeal cells, suggesting that the K channel contributes a dominant role to the RVD function and provides an approach to identify the activation of various K channels.
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| http://dx.doi.org/10.1021/acsbiomaterials.3c00771 | DOI Listing |
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