Insights into the inhibitory activities of neolignans and diarylnonanoid derivatives from nutmeg ( Houtt.) seeds on soluble epoxide hydrolase using and approaches. | LitMetric
Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea.
Published: December 2023
AI Article Synopsis
Article Abstract
Two new neolignans, myrifralignans F-G ( and ), four new diarylnonanoid derivatives, myrifragranones A-D (-), and 18 known compounds were isolated and structurally elucidated from nutmeg ( Houtt.) seeds. The absolute configurations of these secondary metabolites were determined using the electronic circular dichroism technique. The inhibitory potential of these isolated compounds on soluble epoxide hydrolase (sEH) was investigated for the first time. Among them, malabaricones B and C ( and ) and four new compounds - displayed inhibitory activities against sEH, with IC values ranging from 14.24 to 46.35 µM. Additionally, the binding mechanism, key binding interactions, stability, and dynamic behaviour of the active compounds with the sEH enzyme were analysed using molecular docking and dynamics simulations. Our findings suggest that nutmeg could become a promising natural source for discovering and developing new sEH inhibitors.
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