AI Article Synopsis
- - Minoxidil is the only FDA-approved topical treatment for androgenetic alopecia (hair loss), showing effectiveness in 30%-40% of users, especially 50% of men, but its success depends on its conversion by the enzyme SULT1A1.
- - The study aimed to identify and characterize the activity of SULT1A1 in various plant extracts to potentially enhance minoxidil's effectiveness.
- - Out of 10 botanical extracts tested, seven showed significant SULT1A1 activity, suggesting they could be used as natural supplements to improve minoxidil response in hair loss treatments.
Article Abstract
Background: Minoxidil is the only US FDA approved topical drug for the treatment of androgenetic alopecia (AGA). Minoxidil is effective in hair re-growth in 30%-40% of patients and 50% of males. To exert its hair growing effect, minoxidil must be sulfonated in the scalp by the minoxidil sulfotransferase enzyme (SULT1A1). Low scalp SULT1A1 correlates with lack of minoxidil response; thus, supplementing the scalp SULT1A1 with naturally occurring minoxidil sulfotransferase enzymes could potentially improve treatment outcomes in AGA patients.
Methods: In this study, we set to characterize SULT1A1 activity in various plants.
Results: From the 10 common botanical extracts we have studied, seven exhibited significant activity toward minoxidil as a substrate; thus, providing a potential novel paradigm to increase minoxidil response with natural supplements.
Conclusion: To the best of our knowledge, this is the first study to characterize naturally occurring minoxidil sulfotransferase enzymes in plants.
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| http://dx.doi.org/10.1111/jocd.15980 | DOI Listing |
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