From the 1870s through the early 20th century, physicians frequently relied upon nutritive enemata to succor patients suffering from bowel obstructions and other disorders of the gastrointestinal system. Far from extraordinary or outlandish, this therapy was used on paupers and presidents alike, including on Garfield and McKinley after their assassination attempts. The medical milieu of the late 19th century provided particularly promising circumstances for its practice, with the rise of allopathic medicine generally-and surgery especially-coinciding with flourishing research on the physiology of nutrition. Although ongoing discussions debated the merits of different methods and various ingredients, few in the United States or Europe doubted the efficacy of rectal alimentation. However, in the early 20th century, new studies utilizing biochemistry demonstrated the inability of such instillations to provide significant calories or protein, and the intervention fell from favor. Proctoclysis-or rectal hydration-remained standard of care for the next 20 years, strongly supported by John B. Murphy and other surgeons. Ultimately, intravenous hydration and, much later, total parenteral nutrition replaced the rectal route.
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http://dx.doi.org/10.1097/AS9.0000000000000039 | DOI Listing |
Maria Almuedo-Castillo is a Junior Group Leader at the Andalusian Center for Development Biology (CABD). Maria's group studies how mechanical forces are translated into the gene regulatory signals that impact a cell. We spoke to Maria over Teams to learn more about her early-career research, her transition into being a group leader, and her insights into navigating the academic profession.
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Surgical and Transplant Intensive Care Unit, 108 Military Central Hospital, Hanoi, Vietnam.
Hippocampus
January 2025
Department of Neurobiology and Biophysics, University of Washington School of Medicine, Washington National Primate Research Center, Seattle, Washington, USA.
During the 1990s and early 2000s, research in humans and in the nonhuman primate model of human amnesia revealed that tasks involving free viewing of images provided an exceptionally sensitive measure of recognition memory. Performance on these tasks was sensitive to damage restricted to the hippocampus as well as to damage that included medial temporal lobe cortices. Early work in my laboratory used free-viewing tasks to assess the neurophysiological correlates of recognition memory, and the use of naturalistic visual exploration opened rich avenues to assess other aspects of the impact of eye movements on neural activity in the hippocampus and entorhinal cortex.
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Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USA.
In 1979, I joined Jim Ranck's group in Brooklyn and began recording hippocampal neurons. The first project was to record single neurons across three behaviors in different chambers: pellet retrieval on a radial-arm maze, bar-pressing for food reward in an operant chamber, and maternal pup-retrieval in a large home box. We found spatial firing in all three chambers, with a single-neuron's firing pattern unpredictable from one chamber to the next.
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Medicine and Surgery, Foresterhill Health Campus, Aberdeen, GBR.
Untreated obstruction of the urinary tract can result in urinary stasis, hydronephrosis, and infection, which in turn lead to tissue damage, chronic renal failure, and potentially death. Renal stones have afflicted humanity throughout history, with surgical approaches evolving significantly over time. This review explores the origins and major developments in surgical techniques for renal stones, enhancing our understanding of how modern procedures have evolved.
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