[This corrects the article DOI: 10.1039/D1NA00444A.].
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http://dx.doi.org/10.1039/d3na90084c | DOI Listing |
Biochimie
May 2024
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Cholesterol oxidases (ChOxes) are enzymes that catalyze the oxidation of cholesterol to cholest-4-en-3-one. These enzymes find wide applications across various diagnostic and industrial settings. In addition, as a pathogenic factor of several bacteria, they have significant clinical implications.
View Article and Find Full Text PDFNanoscale Adv
August 2023
CNRS, UMR 7244, CSPBAT, Laboratoire de Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques Université Paris 13, Sorbonne Paris Nord, 1 Rue Chablis 93000 Bobigny France
[This corrects the article DOI: 10.1039/D1NA00444A.].
View Article and Find Full Text PDFMol Genet Metab Rep
September 2023
Izmir Katip Celebi University, Tepecik Research and Training Hospital, Department of Pediatrics, Division of Pediatric Metabolism, Izmir, Turkey.
Background: Cerebral organic acid disorders are progressive neurometabolic diseases characterized by neurologic dysfunction. Glutaric aciduria type I (GA-I) and L-2-hydroxyglutaric aciduria (L2HGA) are the main cerebral organic acid disorders. They are both classified as, and it is suggested that these two disorders may share a common metabolic pathway.
View Article and Find Full Text PDFBiochem Biophys Res Commun
February 2023
Peoples' Friendship University of Russia (RUDN University), Moscow, Russia; A.P. Avtsyn Research Institute of Human Morphology, Moscow, Russian Federation.
Mammalian spermatozoa are highly energized cells in which most of the proteins and activated signaling cascades are involved in the metabolic pathways. Flavin adenine dinucleotide (FAD) has one of the most important roles in the correct functional activity of spermatozoa since it acts as a cofactor for flavoenzymes, critical for proper metabolism and predominantly located in mitochondria. Non-invasive, vital and non-traumatic examination of sperm FAD level and microenvironment could be performed by fluorescence lifetime imaging microscopy (FLIM).
View Article and Find Full Text PDFACS Synth Biol
December 2022
School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, Alabama36849, United States.
CRISPR/Cas9-mediated knock-in (KI) has a wide application in gene therapy, gene function study, and transgenic breeding programs. Unlike gene therapy, which requires accurate KI to correct gene mutation, transgenic breeding programs can accept robust KI as long as integration does not interrupt normal gene functions and result in any negative pleiotropic effects. High KI efficiency is required to reduce the breeding cost and shorten the breeding period, especially in transferring multiple foreign genes to a single individual.
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