AI Article Synopsis
- Dengue virus (DENV) infection includes three phases: early acute, late acute, and convalescent, leading to varying severities such as dengue fever, dengue hemorrhagic fever, and dengue shock syndrome.
- Interferons (IFNs) play a key role in the immune response to DENV, but the specific patterns of interferon-regulated genes (the "interferome") in dengue patients have not been thoroughly studied.
- The research reveals that the immune response involves many interferon-regulated genes, influencing processes like cytokine signaling and cell cycle regulation, suggesting certain genes may serve as biomarkers for disease severity.
Article Abstract
Dengue virus (DENV) infection manifests as a febrile illness with three distinct phases: early acute, late acute, and convalescent. Dengue can result in clinical manifestations with different degrees of severity, dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Interferons (IFNs) are antiviral cytokines central to the anti-DENV immune response. Notably, the distinct global signature of type I, II, and III interferon-regulated genes (the interferome) remains uncharacterized in dengue patients to date. Therefore, we performed an in-depth cross-study for the integrative analysis of transcriptome data related to DENV infection. Our systems biology analysis shows that the anti-dengue immune response is characterized by the modulation of numerous interferon-regulated genes (IRGs) enriching, for instance, cytokine-mediated signaling (e.g., type I and II IFNs) and chemotaxis, which is then followed by a transcriptional wave of genes associated with cell cycle, also regulated by the IFN cascade. The adjunct analysis of disease stratification potential, followed by a transcriptional meta-analysis of the interferome, indicated genes such as , , and as potential suitable biomarkers of disease severity. Thus, this study characterizes the landscape of the interferome signature in DENV infection, indicating that interferome dynamics are a crucial and central part of the anti-dengue immune response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449254 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1243516 | DOI Listing |
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