AI Article Synopsis
- Garbractin A is a complex compound with a unique dodecane structure, discovered in the fruit of a specific plant.
- Researchers also identified five new similar compounds, known as garcibracteatones A-E.
- The study tested these compounds' effects on insulin-resistant liver cells, finding that several increased glucose consumption, suggesting they might be useful in treating high blood sugar levels.
Article Abstract
Garbractin A (), a structurally complicated polycyclic polyprenylated acylphloroglucinol (PPAP) with an unprecedented 4,11-dioxatricyclo[4.4.2.0] dodecane skeleton, was isolated from the fruits of , along with five new biosynthetic analogues named garcibracteatones A-E (-). Their structures containing absolute configurations were revealed using spectroscopic data, the residual dipolar coupling-enhanced NMR approach, and quantum chemical calculations. The antihyperglycemic effect of these PPAPs (- was evaluated using insulin-resistant HepG2 cells (IR-HepG2 cells) induced through palmitic acid (PA). Compounds , , and were found to significantly promote glucose consumption in the IR-HepG2 cells and, therefore, may hold potential as candidates for treating hyperglycemia.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448683 | PMC |
| http://dx.doi.org/10.1021/acsomega.3c04947 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!