Therapeutic Management of a Case of Severe Psoriasis Coexistent with Bullous Pemphigoid in the Elderly.

Psoriasis (Auckl)

Dermatology Unit, Azienda Unità Sanitaria Locale- IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Published: August 2023

AI Article Synopsis

  • Scientists don't have a standard way to treat people who have both psoriasis and bullous pemphigoid, even though psoriasis can raise the chances of getting the other disease.
  • In a case, an elderly patient with psoriasis got both diseases and got better after taking a medicine called dymethylfumarate.
  • When dymethylfumarate was stopped due to a side effect, another medicine called risankizumab was given, and the patient didn't have any more problems from the diseases.

Article Abstract

A standardised therapeutic approach to coexistent psoriasis and bullous pemphigoid is lacking, although psoriasis is associated with an increased risk of developing bullous pemphigoid. Here, we report an elderly psoriatic patient who developed a refractory bullous pemphigoid and experienced clearance of both diseases following treatment with dymethylfumarate. Due to lymphopenia, this treatment was stopped and the patient was administered risankizumab without relapses. Dymethylfumarate may be able to inhibit the recruitment of neutrophils and monocytes into the skin. Therefore, thanks to pleiotropic effects, dymethylfumarate could be an effective treatment in psoriatic patients who develop bullous pemphigoid.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460171PMC
http://dx.doi.org/10.2147/PTT.S417427DOI Listing

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