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Fractional CO2 Laser Versus Microneedling Combined with Narrowband Ultraviolet and Topical Steroid for Treating Non-Segmental Vitiligo in Treatment-Resistant Localizations: A Comparative Randomized Clinical Trial Study.
J Lasers Med Sci
August 2024
Skin and Stem Cell Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Vitiligo poses a significant challenge, particularly in treatment-resistant areas such as acral regions. This study aimed to evaluate the effectiveness and safety of combining fractional CO2 laser and microneedling with conventional therapies for non-segmental vitiligo in resistant areas. A randomized clinical trial with a paired design was conducted on 84 individuals with non-segmental vitiligo and treatment-resistant lesions.
View Article and Find Full Text PDFWhole-body and targeted narrowband ultraviolet B phototherapy effectively stabilize acral vitiligo with negligible repigmentation beyond wrists and ankles: Results from a split-body randomized controlled trial.
Photodermatol Photoimmunol Photomed
March 2024
Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Background: Narrowband ultraviolet B (NB-UVB) phototherapy promotes stability and repigmentation in vitiligo. No studies have compared targeted NB-UVB with whole-body NB-UVB in treatment of acral vitiligo.
Objectives: This randomized split-body study compared whole-body NB-UVB with targeted NB-UVB in inducing stability and repigmentation in acral vitiligo.
Characteristics and decreased Vitiligo Area Scoring Index of vitiligo patients with narrowband-UVB phototherapy in Yogyakarta, Indonesia.
Dermatol Reports
December 2023
Department of Dermatology and Venereology Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta; Dr. Sardjito General Hospital, Yogyakarta, Indonesia.
Narrowband ultraviolet-B (NB-UVB) phototherapy is the mainstay of vitiligo therapy. The response can be evaluated using the vitiligo area scoring index (VASI) and repigmentation grade. However, few studies used VASI to evaluate phototherapy response and there are no definitive data on the reduction of VASI.
View Article and Find Full Text PDFA Comparative Study to Evaluate the Efficacy of Fractional CO Laser + PRP Vs. Fractional CO Laser Alone in Patients with Vitiligo.
J Cutan Aesthet Surg
January 2023
Department of Dermatology, JLN Medical College, Ajmer, Rajasthan, India.
Introduction: Vitiligo is a multifactorial acquired disorder clinically characterized by amelanotic lesions on the skin, due to destruction of melanocytes. The course of vitiligo is unpredictable. Vitiligo causes significant psychological impact and cosmetic disfigurement.
View Article and Find Full Text PDFExploring the Efficacy of Fractional Carbon Dioxide Laser as an Add-on Combination to Conventional Therapies for Treatment-Resistant Vitiligo (A Review Article).
J Lasers Med Sci
November 2023
Mental Health Research Center, Social Injury Prevention Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Vitiligo, a dermatological disorder that leads to depigmented skin patches, presents a significant challenge, particularly in resistant areas such as acral regions. Fractional CO2 laser therapy holds promise as an adjunct to conventional treatment, enhancing repigmentation. This review comprehensively explores its efficacy and safety in resistant-to-treatment vitiligo.
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