Semantic cognition and numerical cognition are dissociable faculties with separable neural mechanisms. However, recent advances in the cortical topography of the temporal and parietal lobes have revealed a common organisational principle for the neural representations of semantics and numbers. We discuss their convergence and divergence through the prism of topography.
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http://dx.doi.org/10.1016/j.tics.2023.08.004 | DOI Listing |
Neuropsychologia
January 2025
Neuroscience Area, SISSA, Trieste, Italy; Dipartimento di Medicina dei Sistemi, Università di Roma-Tor Vergata, Roma, Italy.
Although gesture observation tasks are believed to invariably activate the action-observation network (AON), we investigated whether the activation of different cognitive mechanisms when processing identical stimuli with different explicit instructions modulates AON activations. Accordingly, 24 healthy right-handed individuals observed gestures and they processed both the actor's moved hand (hand laterality judgment task, HT) and the meaning of the actor's gesture (meaning task, MT). The main brain-level result was that the HT (vs MT) differentially activated the left and right precuneus, the left inferior parietal lobe, the left and right superior parietal lobe, the middle frontal gyri bilaterally and the left precentral gyrus.
View Article and Find Full Text PDFNeurosurg Rev
January 2025
Department of Neurosurgery, Hospital Universitario Fundación Jiménez Díaz, Av. De los Reyes Católicos, 2, Madrid, 28040, Spain.
Matched-controlled long-term disease evaluation and neuropsychological outcomes derived from deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson´s disease (PD) are lacking, with inconsistent results regarding the cognitive impact of this procedure. Here we study the long-term effects associated to DBS comparing outcomes with a matched control group. A prospective observational study of 40 patients with PD with bilateral STN-DBS, with a mean follow-up of 9 (6-12) years was conducted.
View Article and Find Full Text PDFEur J Hum Genet
January 2025
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Polycomb group (PcG) and Trithorax group (TrxG) complexes represent two major components of the epigenetic machinery. This study aimed to delineate phenotypic similarities and differences across developmental conditions arising from rare variants in PcG and TrxG genes, using data-driven approaches. 462 patients with a PcG or TrxG-associated condition were identified in the DECIPHER dataset.
View Article and Find Full Text PDFJ Gen Intern Med
January 2025
Veterans Administration Healthcare System, Portland, OR, USA.
Background: Chronic kidney disease (CKD) is associated with incident cognitive impairment (ICI) and disproportionately affects older adults and Black persons.
Objective: To determine (1) whether age or race differences exist in the association of CKD and ICI and (2) whether cognitive trajectories differ in people with and without CKD.
Design: Nationwide cohort study.
Neuropsychologia
January 2025
Faculty of Psychology and Educational Sciences, University of Geneva, 40 Boulevard du Pont d'Arve, 1205 Geneva, Switzerland. Electronic address:
Background: Word production difficulty is one of the most common and persisting symptoms in people suffering from aphasia (i.e., anomia).
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