AI Article Synopsis
- Hippocampal Sclerosis (HS) can occur alongside other brain lesions in children, leading to persistent seizures even after functional hemispherectomy (FH), a surgical procedure to remove one hemisphere of the brain.
- A retrospective study identified three children who developed contralateral HS after undergoing FH for unilateral cortical malformations, all of whom continued to experience seizures post-surgery.
- The research suggests that the underlying mechanisms for contralateral HS in these cases are unclear, but genetic mutations may influence seizure outcomes after epilepsy surgery.
Article Abstract
Purpose: Hippocampal Sclerosis (HS) may co-exist with temporal or extratemporal lesions (dual pathology) in children and is usually ipsilateral to the radiological lesion. Here were report three cases with extensive hemispheric cortical malformation and drug resistant epilepsy who had persistent seizures after functional hemispherectomy (FH) and developed contralateral HS after the surgery.
Methods: This retrospective study enrolled children who underwent FH and developed contralateral HS after surgery. Their clinical, EEG, radiological and pathological data were reviewed and summarized.
Results: Ninety-five children underwent FH during the study period; Three cases (3.2%) were eligible. They all had unilateral extensive hemispheric cortical malformation who underwent FH between 3 and 5 months of age with no clinical, EEG or radiological suggestion for involvement of contralateral hemisphere prior to FH. All three patients had persisting seizures after FH. Contralateral HS was detected between 2.2 to 3.7 years after FH in all three cases. Two of the patients showed pathogenic variants in GATOR1 pathway genes.
Conclusions: The genesis of contralateral HS in the reported patients remains unexplained. The presence and distribution of "second-hit" somatic mutations may play an important role in governing the seizure outcomes of epilepsy surgery in patients with apparently unilateral malformations of cortical development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.seizure.2023.08.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Eruptive keratoacanthoma secondary to immune checkpoint inhibitors: a narrative review.
Arch Dermatol Res
January 2025
Department of Dermatology, College of Medicine, The Ohio State University Wexner Medical Center, 540 Officenter Place, Columbus, OH, 43230, USA.
The use of immunotherapy is an emerging treatment option for advanced malignancies. Cutaneous adverse events following cancer immunotherapy are well-documented in the literature. The rarer cutaneous adverse effects are less characterized, including eruptive keratoacanthomas (KA).
View Article and Find Full Text PDFBackground: Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Since IL-1 has been shown to play a key role in the etiology of different autoinflammatory diseases, blocking its pathway has become an important therapeutic target, even in neonates.
Aims: We aimed to report our experience in using anakinra to treat specific neonatal inflammatory conditions.
Pulmonary Dysfunction in Children with Dystrophinopathy: A Cross-Sectional Study.
Indian J Pediatr
January 2025
Centre of Excellence and Advanced Research for Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Objectives: To observe the prevalence of impaired pulmonary function during various phases of the disease course in children aged 5-18 y with dystrophinopathy. The correlation between different parameters of pulmonary dysfunction and motor function was also studied.
Methods: One hundred and thirty-three confirmed cases of Duchenne muscular dystrophy (DMD), fulfilling predefined inclusion and exclusion criteria were evaluated.
Temporomandibular joint septic arthritis: a report of thirteen cases and a systematic review of the literature.
Rheumatol Int
January 2025
Department of Oral and Maxillofacial Surgery, U1008 - Advanced Drug Delivery Systems, Univ. Lille, CHU Lille, INSERM, Lille, F-59000, France.
Introduction: Temporomandibular joint (TMJ) septic arthritis is a rare frequently misdiagnosed condition with non-specific symptoms. We present our experience of thirteen cases of TMJ septic arthritis and perform a systematic review of the literature to collate the multiple characteristics of this condition.
Material And Method: A total of 133 cases of TMJ septic arthritis in humans across 62 studies were analyzed by searching PubMed, Cochrane Library, DOAJ and ClinicalTrials.
The mediating role of ruminations in the relationship between negative and positive effects of indirect trauma in police officers.
Psychol Trauma
January 2025
Institute of Social Sciences, Police Academy.
Objective: Professionals working with people after traumatic events can experience both secondary traumatic stress (STS) and secondary posttraumatic growth (SPTG) as a result of exposure to indirect trauma; in both cases, a key role in their development is played by ruminations about the events experienced by the client. The aim of the study was to establish the relationship between STS, ruminations, and SPTG and determine the mediating role of ruminations in the relationship between STS and SPTG in a group of police officers.
Method: The study examined 682 police officers exposed to indirect trauma.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!