AI Article Synopsis
- The study investigated the effects of alpha-melanocyte stimulating hormone (MSH) on lordosis behavior in rats, examining two methods of administration: intracerebroventricular (ICV) and subcutaneous (SC).
- Previous experiments suggested MSH significantly influenced lordosis, but new findings imply that its effects might not be exclusive, as similar outcomes were observed without MSH.
- Results showed that SC MSH facilitated sexual receptivity in low-responding subjects while ICV MSH inhibited receptivity and had lasting effects even after a week.
Article Abstract
The effects of 200 ng of intracerebroventricularly (ICV) and 20 micrograms of subcutaneously (SC) administered alpha-melanocyte stimulating hormone (MSH) on lordosis in rats were examined. Previous research, employing crossover designs, has revealed significant effects of MSH on lordosis. The results of Experiments 1a and 1b suggest that similar designs produce significant effects even in the absence of MSH. Thus, it is not clear that previous results were due exclusively to an action of MSH. Experiment 2 employed a modification of previous procedures and indicated that MSH administered either SC or ICV inhibited receptivity in subjects displaying high levels of responding. Moreover, MSH administered SC was also found to facilitate receptivity in subjects displaying low levels of responding. However, a possible long term inhibitory action of MSH on receptivity was also revealed. Because animals were tested repeatedly, this brought into question the results of Experiment 2. Procedures were revised accordingly and the effects of MSH re-examined. The results of Experiment 3 indicated that MSH administered SC facilitated receptivity while MSH administered ICV inhibited receptivity. In addition, MSH administered ICV exerted an inhibitory effect one week after administration. Therefore, MSH appears to exert both short and long-acting effects on sexual receptivity.
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