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Quantifying Long-Time Hydrogen-Deuterium Exchange of Bovine Serum Albumin with Hydrogen-Deuterium Exchange Small-Angle Neutron Scattering.
J Phys Chem B
December 2024
Center for Neutron Science, Department of Chemical and Biomolecular Engineering, College of Engineering, University of Delaware, Newark, Delaware 19711, United States.
Hydrogen-deuterium exchange (HDX) measured by small-angle neutron scattering (HDX-SANS) is used to measure HDX in bovine serum albumin (BSA) under different temperatures and formulation conditions. HDX-SANS measurements are performed at 40, 50, and 60 °C in DO after storing proteins at 4 °C for 1 week to pre-exchange the readily accessible hydrogens. This enables us to probe the long-time HDX of protons at the core of the BSA proteins, which is more challenging for solvent molecules to access.
View Article and Find Full Text PDFAdipsic arginine vasopressin deficiency: challenges in managing the intricate interplay of adipsia with polyuria.
BMJ Case Rep
October 2024
Endocrinology and Metabolism, All India Institute of Medical Science, Bhopal, Madhya Pradesh, India
Article Synopsis
- Adipsic arginine vasopressin deficiency (AAVP-D) occurs due to hypothalamic dysfunction, often linked to conditions like craniopharyngiomas, which makes management difficult since key mechanisms for regulating plasma osmolality are impaired.
- Patients with AAVP-D can suffer from severe dehydration and elevated sodium levels (hypernatraemia), leading to frequent emergency visits despite treatment with desmopressin, an arginine vasopressin analogue.
- A case study highlights the successful management of AAVP-D through careful water intake regulation and desmopressin administration, resulting in stable serum sodium levels (140-150 mmol/L) and no emergency visits over a three-month period.
Anti-fatigue effect of an enzymatically derived deer velvet extract through muscle damage recovery and improvement of antioxidant levels.
J Ethnopharmacol
January 2025
Department of Oral Pathology, School of Dentistry, Jeonbuk National University, Jeonju, Republic of Korea; Non-Clinical Evaluation Center Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Republic of Korea. Electronic address:
Ethnopharmacological Relevance: Deer velvet (DV) has been extensively used in traditional Oriental medicine to treat various diseases. Its pharmacological spectrum encompasses tonicity, longitudinal bone growth of adolescence, blood retention, hemopoiesis facilitation, enhancement of organ function, physical function improvement, and augmentation of physical vitality. Among its myriad effects, DV notably exhibits anti-fatigue properties; however, its specific mode of action is yet to be fully elucidated.
View Article and Find Full Text PDFPlacental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia development.
Biol Res
August 2024
Department of Women's Health, University of Tübingen, 72076, Calwerstraße 7/6, Tübingen, Germany.
After menstruation the uterine spiral arteries are repaired through angiogenesis. This process is tightly regulated by the paracrine communication between endometrial stromal cells (EnSCs) and endothelial cells. Any molecular aberration in these processes can lead to complications in pregnancy including miscarriage or preeclampsia (PE).
View Article and Find Full Text PDFBackground And Aims: Population aging is fueling an epidemic of age-related chronic diseases. Managing risk factors and lifestyle interventions have proven effective in disease prevention. Epidemiological studies have linked markers of poor hydration with higher risk of chronic diseases and premature mortality.
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