AI Article Synopsis
- The study focuses on the lack of research connecting salivary metabolomics to biomarkers for Sjögren's syndrome (SS).
- The research involved analyzing saliva samples from 18 female SS patients and 22 healthy controls using advanced mass spectrometry, revealing 91 metabolites with different levels in these groups.
- Out of these, 16 metabolites were confirmed as significant, with alanine, isovaleric acid, and succinic acid showing strong potential as biomarkers due to their high sensitivity and specificity, indicating they could help in developing a salivary diagnostic test for SS.
Article Abstract
Introduction: Despite the rise of metabolomics over the past years, and particularly salivary metabolomics, little research on Sjögren's syndrome (SS) biomarkers has focused on the salivary metabolome.
Objectives: This study aims to identify metabolites that could be used as biomarkers for SS.
Methods: Using the software called XCMS online, the salivary metabolic profiles obtained with liquid chromatography coupled to high-resolution mass spectrometry for 18 female SS patients were compared to those obtained for 22 age-matched female healthy controls.
Results And Conclusion: A total of 91 metabolites showed differential expression in SS patients. A putative identification was proposed with the use of a database for 37 of these metabolites and, of these, 16 identifications were confirmed. Given the identified metabolites, some important metabolic pathways, such as amino acid metabolism, purine metabolism, or even the citric acid cycle seem to be affected. Through the analyses of the ROC (receiver operating characteristic) curves, three metabolites, namely alanine, isovaleric acid, and succinic acid, showed both good sensitivity (respectively 1.000, 1.000, and 0.750) and specificity (respectively 0.692, 0.615, and 0.692) for identifying SS and could then be interesting biomarkers for a potential salivary diagnosis test.
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| http://dx.doi.org/10.1007/s11306-023-02040-8 | DOI Listing |
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