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The relationship between neurogenic dysphagia, stroke-associated pneumonia and functional outcome in a cohort of ischemic stroke patients treated with mechanical thrombectomy. | LitMetric

AI Article Synopsis

  • Mechanical thrombectomy (MT) is frequently used to treat acute ischemic stroke patients with large vessel occlusion (LVO), and recent studies show a significant increase in the risk of dysphagia and pneumonia in these patients.
  • This study analyzed data from 567 patients who underwent MT from 2016 to 2019, finding a 75.1% prevalence of dysphagia and a 23.3% incidence of stroke-associated pneumonia (SAP).
  • Dysphagia was identified as a key predictor of poor functional outcomes at 3 months, and the relationship between dysphagia and these outcomes was not influenced by the development of SAP.

Article Abstract

Introduction: Mechanical thrombectomy (MT) is an established treatment approach in acute ischemic stroke patients with large vessel occlusion (LVO). Recent studies suggest that the prevalence of dysphagia and pneumonia risk is increased in this patient population. The aim of this study was to systematically evaluate the prevalence, predictors, and influence of neurogenic dysphagia for 3-month outcome in a large population of patients receiving MT and to elucidate the relationship between dysphagia, stroke-associated pneumonia (SAP) and medium-term functional outcome.

Materials And Methods: Data of a prospective collected registry of patients with LVO and MT between 2016 and 2019 were analyzed retrospectively. Binary logistic regression was carried out to determine predictors for dysphagia and 3-month outcome as measured by the modified Rankin Scale, respectively. A mediation analysis was performed to investigate the mediating influence of intercurrent SAP.

Results: A total of 567 patients were included in the study. Mean age was 73.4 years, 47.8% of the patients were female, and median NIHSS was 15.0. The prevalence of dysphagia was 75.1% and 23.3% of all patients developed SAP. In the regression analysis, dysphagia was one of the main independent predictors for poor functional outcome at 3 months. The mediator analysis revealed that the effect of dysphagia on the functional outcome at 3 months was not mediated by the occurrence of SAP.

Discussion: The prevalence of dysphagia is high and exerts both negative short- and medium-term effects on patients with large vessel occlusion who undergo MT.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632272PMC
http://dx.doi.org/10.1007/s00415-023-11940-7DOI Listing

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