Dysregulation of iron metabolism in chronic hepatitis C (CHC) is a significant risk factor for hepatic cirrhosis and cancer. We studied if known genetic variants related to iron homeostasis associate with liver disease progression in CHC. Retrospective analysis included 249 CHC patients qualified for antiviral therapy between 2004 and 2014. For all patients, nine SNPs within , , , , , , and genes were genotyped. Expression of selected iron-related genes, was determined with qRT-PCR in 124 liver biopsies, and mRNA expression of co-inhibitory receptors (, , ) was measured in 79 liver samples. rs884409, rs368328, rs7385804, and rs855791 associated with histopathological changes in liver tissue at baseline. The combination of minor allele in rs976552 and rs884409 linked with higher prevalence of hepatocellular carcinoma (HCC) during follow up (OR 8.1 CI 2.2-29.2; = 0.001). Minor allele in rs976552 associated with lower hepatic expression of . Tested polymorphisms related to iron homeostasis associate with histopathological changes in the liver. The presence of both rs976552 G and rs884409 G alleles correlates with HCC occurrence, especially in the group of patients with elevated AST (>129 IU/L). rs976552 in could impact immunological processes associated with carcinogenesis in CHC.
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| http://dx.doi.org/10.3390/v15081710 | DOI Listing |
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