For polymer-processing extruders, designing screws via analytical computational models is helpful for reducing experimental costs. However, the current simulation programs cannot predict the melt quality at the screw tip with sufficient accuracy. There are a number of definitions of melt quality in the literature. This paper will review some of these definitions and present how melt quality can be assessed in subsequent work. In this paper, both the thermal and material homogeneity of the melt quality are examined for correlations with the screw performance index. If correlations exist with the screw performance index determined from direct experimental measurement data, these can be used as target values for developing a melt quality prediction model.
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http://dx.doi.org/10.3390/polym15163427 | DOI Listing |
Alzheimers Dement
December 2024
University of Washington, Seattle, WA, USA.
Background: The BRAIN Initiative has stimulated development of novel single cell and spatial molecular approaches to understand human brain structure and function. However, traditional methods for human brain specimen collection, including retrospective archival tissues, have not been optimized for these latest methods. A modernized approach that optimizes tissue quality, anatomical precision, and comprehensive, quantitative neuropathological assessments is needed to maximize the impact of the tremendous investment and remarkable technological advances in human neuroscience research.
View Article and Find Full Text PDFBreastfeed Med
January 2025
Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, INICSA, Córdoba, Argentina.
This study evaluates the impact of various processing steps in the human milk (HM) donation chain on nutritional composition and oxidative biomarkers, specifically focusing on triacylglycerols, glucose, polyphenols, and lipid peroxides. A total of 68 HM samples were collected from the Human Milk Bank of Córdoba (Argentina) between 2022 and 2023. The effects of storage and pasteurization using the Holder method were assessed.
View Article and Find Full Text PDFJ Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Department of Clinical Diagnostics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address:
Introduction: High-dose systemic prednisolone is the cornerstone treatment of many autoimmune- and inflammatory diseases. Since prednisolone shows non-linear protein binding at higher serum concentrations, quantification of the unbound prednisolone concentration is important to understand prednisolone pharmacokinetics. We developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay to quantify protein-unbound prednisolone in serum.
View Article and Find Full Text PDFPoult Sci
December 2024
Department of Poultry Science, University of Georgia, Athens, GA 30602-2772, USA.
Semen cryopreservation is essential for preserving genetic resources and enabling artificial insemination in poultry breeding. However, avian sperm is known to experience detrimental changes during the freezing process. Telmisartan, an angiotensin-II receptor antagonist recognized for its antioxidant properties and ability to activate AMP-activated protein kinase (AMPK), was hypothesized to improve post-thaw semen quality by enhancing mitochondrial function and providing antioxidant protection to sperm.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
December 2024
Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Techniques for sperm cryopreservation have exhibited their potential in male fertility preservation. The use of frozen-thawed sperm in fertilization (IVF) cycles is widespread today. However, many studies reported that cryopreservation might have adverse effects on sperm DNA integrity, motility, and fertilization, probably due to cold shock, intra- and extracellular ice crystals, and excess reactive oxygen species (ROS).
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