Flavonol Extract-Antiradical and Immunomodulating Activities Analysis.

Plants (Basel)

A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, Kazan 420088, Russia.

Published: August 2023

AI Article Synopsis

  • The research focused on extracting and analyzing flavonol compounds from fruits, using techniques like high-performance liquid chromatography.
  • The flavonol extract showed strong antioxidant properties, effectively neutralizing free radicals and enhancing immune cell activity in a specific lymphoblast cell line.
  • The study concluded that these compounds had minimal impact on the leukocyte profile in animals, while also improving metabolic reserves in cells under stress from cyclophosphamide.

Article Abstract

The study of () biological activity is focused on obtaining the crude extract and separation of the flavonol compounds. The extraction and fractionation of fruits, followed by quantitative analysis, were accomplished using high-performance liquid chromatography and Darco G-60 filtering. This approach enabled the quantification of flavonoids within each fraction. The antioxidative, immunomodulating activities and cytotoxicity with respect to the lymphoblast cell line RPMI-1788 were studied. The flavonol extract of has been shown to have a high capacity to neutralize free DPPH and AAPH radicals in vitro. It also caused an accelerated 'respiratory burst' formation of neutrophils and an increase in the metabolic reserves of cells in rats exposed to cyclophosphamide. The reference solution (an equivalent quercetin-rutin blend) contributed to a decrease in lipid peroxidation, intensifying phagocytosis processes. The studied compounds demonstrated their low influence on the leukocyte blood profile in animals.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458422PMC
http://dx.doi.org/10.3390/plants12162976DOI Listing

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