AI Article Synopsis
- Hepatitis B virus (HBV) genotypes E to J are largely understudied, with genotype E mainly found in West Africa and genotypes F and H mostly in America.
- Genotype F is the most different from others and is divided into six subgenotypes, while genotypes I and J are found in Asia and may have originated from genetic mixing.
- The limited data from sub-Saharan Africa and Latin America in research studies highlights the need for more investigations into these less-researched HBV genotypes.
Article Abstract
Hepatitis B virus (HBV) genotypes E to J are understudied genotypes. Genotype E is found almost exclusively in West Africa. Genotypes F and H are found in America and are rare in other parts of the world. The distribution of genotype G is not completely known. Genotypes I and J are found in Asia and probably result from recombination events with other genotypes. The number of reported sequences for HBV genotypes E to J is small compared to other genotypes, which could impact phylogenetic and pairwise distance analyses. Genotype F is the most divergent of the HBV genotypes and is subdivided into six subgenotypes F1 to F6. Genotype E may be a recent genotype circulating almost exclusively in sub-Saharan Africa. Genotype J is a putative genotype originating from a single Japanese patient. The paucity of data from sub-Saharan Africa and Latin America is due to the under-representation of these regions in clinical and research cohorts. The purpose of this review is to highlight the need for further research on HBV genotypes E to J, which appear to be overlooked genotypes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459053 | PMC |
| http://dx.doi.org/10.3390/microorganisms11081908 | DOI Listing |
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