AI Article Synopsis
- Glioblastoma is a highly aggressive CNS tumor that often resists chemotherapy, making treatment challenging.* -
- Researchers tested a combination of Aloe-emodin (AE) and temozolomide (TMZ) on drug-resistant glioma cell lines (NULU and ZAR) and found that this combination significantly inhibits cell growth and reduces drug resistance.* -
- The study also indicated that AE combined with TMZ slows the migration and colony formation of glioblastoma cells, suggesting AE could enhance the effectiveness of traditional treatments against this cancer.*
Article Abstract
Glioblastoma, the most dangerous and aggressive type of CNS tumor, appears resistant to many chemotherapy drugs. In the patient-derived glioma cell lines NULU and ZAR, which exhibit drug-resistant phenotypes, we investigated the effect of combined AE (Aloe-emodin) and TMZ (temozolomide) and found a significant additive inhibitory effect on cell growth and a promising cytotoxic effect on both cell lines compared to treatment with single agents. We also examined the effect of combined AE and TMZ treatment on the drug-resistance protein MGMT. The results suggest that using AE combined with traditional drugs restores drug resistance in both primary resistant cell lines (NULU and ZAR). Furthermore, migration assays and scratch tests showed that the combined use of AE and TMZ can slow down the colony formation and migration of glioblastoma cells. These convincing results suggest that AE could be a natural adjuvant agent to potentiate the effects of traditional drugs (TMZ) and overcome drug resistance in glioblastoma cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458156 | PMC |
| http://dx.doi.org/10.3390/molecules28166024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!