AI Article Synopsis
- The study investigates the impact of different materials (CoCr vs. titanium alloy) used in knee implants on periprosthetic bone stress and stress shielding.
- The research employs a finite element model to compare how these materials influence bone mineral density, with a particular focus on the effects of a cementless, highly porous titanium implant versus a cemented CoCr implant.
- Results indicate that the titanium component produces higher bone stresses and less stress shielding, which could result in reduced bone resorption after total knee arthroplasty.
Article Abstract
Due to the high stiffness of the biomaterials used in total knee arthroplasty, stress shielding can lead to decreased periprosthetic bone mineral density and bone resorption. As different materials and 3D-printed highly porous surfaces are available for knee femoral components from the industry nowadays, this study aimed to compare the effects of two same-design cruciate-retaining femoral components, made with CoCr and titanium alloy, respectively, on periprosthetic bone stresses through a finite element model of the implanted knee in order to evaluate the induced stress shielding. Moreover, the effect of the cementless highly porous surface of the titanium implant was analyzed in comparison to the cemented interface of the CoCr implant. The von Mises stresses were analyzed in different periprosthetic regions of interest of the femur with different configurations and knee flexion angles. The titanium component induced higher bone stresses in comparison with the CoCr component, mostly in the medial compartment at higher knee flexion angles; therefore, the CoCr component led to more stress shielding. The model was revealed to be effective in describing the effects of different femoral component materials on bone stress, highlighting how a cementless, highly porous titanium femoral component might lead to less stress shielding in comparison to a cemented CoCr implant with significant clinical relevance and reduced bone resorption after total knee arthroplasty.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10456576 | PMC |
| http://dx.doi.org/10.3390/ma16165605 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nuclear receptor 4A1 Regulates Mitochondrial Homeostasis in Cardiac Post-Ischemic Injury by Controlling Mitochondrial Fission 1 Protein-Mediated Fragmentation and Parkin-Dependent Mitophagy.
Int J Biol Sci
January 2025
Department of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China 510120.
The close interaction of mitochondrial fission and mitophagy, two crucial mechanisms, is key in the progression of myocardial ischemia-reperfusion (IR) injury. However, the upstream regulatory mechanisms governing these processes remain poorly understood. Here, we demonstrate a marked elevation in Nr4a1 expression following myocardial IR injury, which is associated with impaired cardiac function, heightened cardiomyocyte apoptosis, exacerbated inflammatory responses, and endothelial dysfunction.
View Article and Find Full Text PDF3D-Printed Electrohydrodynamic Pump and Development of Anti-Swelling Organohydrogel for Soft Robotics.
Adv Mater
January 2025
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
This study introduces advancements in electrohydrodynamic (EHD) pumps and the development of a 3D-printable anti-swelling organohydrogel for soft robotics. Using digital light processing (DLP)technology, precise components with less than 1% size variation are fabricated, enabling a unique manifold pump array. This design achieves an output pressure of 90.
View Article and Find Full Text PDFDoes Improved Resection Plane Coverage During Shoulder Arthroplasty Influence Proximal Humeral Bone Stress? A Comparison of Circular vs. Elliptical Humeral Heads.
J Shoulder Elbow Surg
December 2024
Department of Mechanical Engineering, Western University, London, ON, Canada; The Roth|McFarlane Hand and Upper Limb Centre, St. Joseph's Hospital, London, ON, Canada; Department of Surgery, Western University, London, ON, Canada. Electronic address:
Introduction: Stress shielding remains a concern following total shoulder arthroplasty using press-fit short humeral stems. While the effect of alterations in implant geometry, positioning, and sizing on stress shielding have been investigated, the effects of coverage of the cortical boundary of the resection plane have not yet been fully explored. The purpose of this study was to quantify the effect of improved cortical coverage using elliptical vs.
View Article and Find Full Text PDFEggshell-derived particle composites with epoxy resin for enhanced radiation shielding applications.
Radiat Environ Biophys
December 2024
Faculty of Radiological Technology, Rangsit University, Pathumthani, 12000, Thailand.
This study explores the development and efficacy of eggshell-derived particle composites with epoxy resin for enhanced radiation shielding applications. Eggshells, primarily composed of calcium carbonate, were processed into particles of three sizes: small, medium, and large. These particles were incorporated into epoxy resin at a 50% weight ratio and characterized using a Laser Particle Size Distribution Analyzer.
View Article and Find Full Text PDFA Chimeric Peptide for Shielding Plant Photosynthetic Systems against Excess Light Stress via Chloroplast-Targeted ROS Quenching.
JACS Au
December 2024
Biomacromolecules Research Team, RIKEN Center for Sustainable Resource Science, Saitama 351-0198, Japan.
The ability to quench reactive oxygen species (ROS) overproduced in plant chloroplasts under light stress conditions is essential for securing plant photosynthetic performance and agricultural yield. Although genetic engineering can enhance plant stress resistance, its widespread application faces limitations due to challenges in successful transformation across plant species and public acceptance concerns. This study proposes a nontransgenic chemical approach using a designed chimeric peptide that scavenges ROS within plant chloroplasts for managing light stress.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!