AI Article Synopsis
- Serum response factor (SRF) is crucial for regulating muscle contraction and motility genes in mural cells of blood vessels, particularly in the retina for proper blood vessel development and function.
- A study on mice with a specific deletion of MC-SRF found varying levels of retinal blood vessel alterations, including vascular bulging and arteriovenous connections, leading to retinal detachment in severe cases.
- These changes resulted in irregular blood pressure and flow, causing hypoxia, as reflected in abnormal electroretinography results, suggesting that the effects are influenced by the local retinal environment rather than solely by the genetic defect.
Article Abstract
Serum response factor (SRF) controls the expression of muscle contraction and motility genes in mural cells (MCs) of the vasculature. In the retina, MC-SRF is important for correct angiogenesis during development and the continuing maintenance of the vascular tone. The purpose of this study was to provide further insights into the effects of MC SRF deficiency on the vasculature and function of the mature retina in mice that carry a MC-specific deletion of . Retinal morphology and vascular integrity were analyzed in vivo via scanning laser ophthalmoscopy (SLO), angiography, and optical coherence tomography (OCT). Retinal function was evaluated with full-field electroretinography (ERG). We found that retinal blood vessels of these mutants exhibited different degrees of morphological and functional alterations. With increasing severity, we found vascular bulging, the formation of arteriovenous (AV) anastomoses, and ultimately, a retinal detachment (RD). The associated irregular retinal blood pressure and flow distribution eventually induced hypoxia, indicated by a negative ERG waveform shape. Further, the high frequency of interocular differences in the phenotype of individual mice points to a secondary nature of these developments far downstream of the genetic defect and rather dependent on the local retinal context.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454173 | PMC |
| http://dx.doi.org/10.3390/ijms241612597 | DOI Listing |
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