Prostate cancer (PC) is polygenic disease involving many genes, and more importantly a host of gene-gene interactions, including transcriptional factors. The gene is a transcriptional target of numerous oncoproteins, and its dysregulation can contribute to tumor progression by abnormal activation of targeted oncogenes. Using data from the Cancer Genome Atlas, we tested the possible involvement of in PC progression. A multi-dimensional scaling (MDS) model was applied to clarify the association of expression with other key genes, such as , , ( and ), , and . An increased expression was associated with higher PC grades and with a worse prognosis. It was also positively related to , , and . Moreover, MDS showed the central role of in influencing the other target genes by its central location on the map. Our study is the first to show a link between expression and other genes involved in PC progression, suggesting a novel role for in PC progression. This network between and through may have an important role in PC progression, as suggested by the association between high expression and unfavorable prognosis in our analysis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454498 | PMC |
| http://dx.doi.org/10.3390/genes14081558 | DOI Listing |
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