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Sub-lethal exposures to bifenthrin impact stress responses and behavior of juvenile Chinook Salmon.
Environ Toxicol Chem
January 2025
Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, Yolo County, CA, 95616USA.
Juvenile Chinook Salmon (Oncorhynchus tshawytscha) populations have decreased substantially in the Sacramento-San Joaquin Delta (Delta) over the past decades, so considerably that two of the four genetically distinct runs are now listed in the Endangered Species Act. One factor responsible for this decline is the presence of contaminants in the Delta. Insecticides, used globally in agricultural, industrial, and household settings, have the potential to contaminate nearby aquatic systems through spray drift, runoff, and direct wastewater discharge.
View Article and Find Full Text PDFFabrication of Hypoxia-Mimicking Supramolecular Hydrogels for Cartilage Repair.
ACS Appl Bio Mater
January 2025
Regenerative Medicine and Stem Cell Laboratory (RMS), Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502 284, Telangana, India.
Despite advancements in chronic arthritis treatment, there remains a significant demand for advanced nanotechnologies capable of efficiently delivering a wide range of therapeutic agents to provide symptomatic relief and facilitate the healing of inflamed cartilage tissue. Considering the significant impact of hypoxia on the development and maintenance of chondral tissue, replicating its effects on stem cells could be a potential approach for the treatment of osteoarthritis (OA). Cobalt is a prominent hypoxia-inducing agent, owing to its ability to activate the hypoxia-inducible factor (HIF) pathway regardless of cellular oxygen levels.
View Article and Find Full Text PDFEffective killing of biofilm by nanoemulsion delivery of plant phytochemicals.
Microbiol Spectr
January 2025
Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, USA.
Unlabelled: is an acid-fast, aerobic, non-motile, and biofilm-forming bacterium. The increasing prevalence of mycobacterial infections makes it necessary to find new methods to combat the resistance of bacteria to conventional antibiotics. is an emerging pathogen that is intrinsically drug resistant due to several factors, including an impermeable cell envelope, drug efflux pumps, target-modifying enzymes, and the ability to form thick, robust biofilms.
View Article and Find Full Text PDFQuinoa Ethanol Extract Ameliorates Cognitive Impairments Induced by Hypoxia in Mice: Insights into Antioxidant Defense and Gut Microbiome Modulation.
J Agric Food Chem
January 2025
College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shaanxi 712100, China.
Quinoa, rich in pharmacologically active ingredients, possesses the potential benefit in preventing cognitive impairments induced by hypoxia. In this study, the efficacy of quinoa ethanol extracts (QEE) consumption (200 and 500 mg/kg/d, respectively) against hypobaric hypoxia (HH)-induced cognitive deficits in mice was investigated. QEE significantly ameliorated hypoxic stress induced by HH, as evidenced by improvements in baseline indices and reductions in hypoxia-inducible factor 1α levels.
View Article and Find Full Text PDFRegulation of pathologic fibroblast functions in digestive diseases: a role for hypoxia?
Am J Physiol Gastrointest Liver Physiol
January 2025
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland.
The recent uncovering of fibroblast heterogeneity has given great insight into the versatility of the stroma. Among other cellular processes, fibroblasts are now thought to contribute to the coordination of immune responses in a range of chronic inflammatory diseases and cancer. While the pathologic roles of myofibroblasts, inflammatory fibroblasts and cancer associated fibroblasts in disease are reasonably well understood, the mechanisms behind their activation remain to be uncovered.
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