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HIV infection is considered a scenario of accelerated aging. Previous studies have suggested a link between aging, frailty, and gut dysbiosis, but there is a knowledge gap regarding the HIV population. Our objective was to compare the fecal bacteriome of older people with HIV (PWH) and non-HIV controls, and to assess potential links between gut dysbiosis and frailty. A total of 36 fecal samples (24 from PWH and 12 from non-HIV controls) were submitted to a metataxonomic analysis targeting the V3-V4 hypervariable region of the 16S rRNA gene. High-quality reads were assembled and classified into operational taxonomic units. Alpha diversity, assessed using the Shannon index, was higher in the control group than in the HIV group ( < 0.05). The relative abundance of the genus was higher in the HIV group ( < 0.001). The presence of was also higher in PWH with depression ( = 0.004), whereas the opposite was observed for the genus ( = 0.004). Our study shows shifts in the composition of the PWH bacteriome when compared to that of healthy controls. To our knowledge, this is the first study suggesting a potential link between depression and gut dysbiosis in the HIV population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452058 | PMC |
| http://dx.doi.org/10.3390/biomedicines11082305 | DOI Listing |
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