AI Article Synopsis
- Tuberculosis (TB) is caused by the airborne bacteria Mycobacterium tuberculosis (Mtb), and while the role of antibodies in protecting against it isn't fully understood, they may play a crucial part in host defense.
- This study analyzed the IgG/IgA memory B cell responses in healthy individuals exposed to TB, identifying a human monoclonal antibody that can protect against the disease by targeting a specific virulence factor called LpqH.
- Findings showed that the protective effects varied depending on the antibody type, with IgG2 and IgA providing the strongest defense, suggesting new avenues for improving TB vaccines and understanding natural immunity.
Article Abstract
Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (Mtb). Whilst a functional role for humoral immunity in Mtb protection remains poorly defined, previous studies have suggested that antibodies can contribute towards host defense. Thus, identifying the critical components in the antibody repertoires from immune, chronically exposed, healthy individuals represents an approach for identifying new determinants for natural protection. In this study, we performed a thorough analysis of the IgG/IgA memory B cell repertoire from occupationally exposed, immune volunteers. We detail the identification and selection of a human monoclonal antibody that exhibits protective activity in vivo and show that it targets a virulence factor LpqH. Intriguingly, protection in both human ex vivo and murine challenge experiments was isotype dependent, with most robust protection being mediated via IgG2 and IgA. These data have important implications for our understanding of natural mucosal immunity for Mtb and highlight a new target for future vaccine development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457302 | PMC |
| http://dx.doi.org/10.1038/s41541-023-00710-1 | DOI Listing |
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