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[Characteristics of Hospitalized Adults with Severe Hyponatremia: A Comparison of Patients with Severe and Very Severe Hyponatremia in Terms of Etiology, Symptoms, Treatment Response, and Mortality].
Rev Med Chil
May 2024
Internos carrera de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Unlabelled: Hyponatremia is the most common hydroelectrolyte disorder in hospitalized patients. It is unclear whether there are differences between severe hyponatremia (<125 mEq/L) and very severe hyponatremia (<115 mEq/L) in terms of etiology, response to therapy, and mortality.
Aim: Describe the etiology, symptoms, response to treatment and mortality of hospitalized adults with severe and very severe hyponatremia.
A nationwide questionnaire study evaluated kidney injury associated with Beni-koji tablets in Japan.
Kidney Int
December 2024
Department of Nephrology, Graduate School of Medicine, Osaka University, Suita, Japan. Electronic address:
Red yeast rice, traditionally used in Asian cuisine and increasingly marketed as a dietary supplement for cholesterol management, has recently been linked to kidney dysfunction in Japan. In late 2023 to early 2024, multiple cases involving specific Beni-koji (red yeast rice) tablets from three different Beni-koji preparations, prompted a safety reevaluation. Although citrinin, a known nephrotoxin of red yeast rice, was not produced by the implicated strains, new safety concerns emerged.
View Article and Find Full Text PDF[Analysis of a family with hypouricemia due to type Ⅰ xanthinuria].
Zhonghua Yi Xue Za Zhi
November 2024
Department of Endocrinology, the Affiliated Hospital of Kunming University of Science and Technology, the First People's Hospital of Yunnan Province, Kunming650000, China.
This article reports a patient presenting with"extremely low uric acid levels in blood and urine"clinically along with reviewing relevant literature to consider a diagnosis of xanthinuria. Peripheral blood samples of the patient and her family were further collected for xanthine dehydrogenase(XDH) gene sequencing, showing that the patient had compound heterozygous mutations in exon 19:c.1995_2006del12(p.
View Article and Find Full Text PDFArticle Synopsis
- SIADH causes low sodium levels (hyponatremia) and decreased uric acid in the body.
- A patient with small-cell lung cancer experienced SIADH and low uric acid (hypouricemia) after taking duloxetine, a medication used for depression and anxiety.
- The patient's condition improved when duloxetine was replaced with mirogabalin, suggesting a link between the medications and these side effects.
Presence of mitochondrial dysfunction in a case of Fanconi syndrome with normoglycemic MODY1.
CEN Case Rep
November 2024
Department of Pediatrics, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, Japan.
Article Synopsis
- Maturity-onset diabetes of the young 1 (MODY1) is linked to large birth size and temporary low blood sugar in newborns, with a specific genetic mutation leading to more severe complications like Fanconi syndrome (FS).
- In a reported case, a patient was diagnosed with MODY1 due to abnormal kidney mitochondria found through electron microscopy before diabetes symptoms appeared, highlighting the complexity of the condition.
- Genetic testing later confirmed a pathogenic variant in the HNF4A gene, suggesting that mitochondrial dysfunction plays a crucial role in the development of both MODY1 and FS in this patient.
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