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Evaluation of BCRP-Related DDIs Between Methotrexate and Cyclosporin A Using Physiologically Based Pharmacokinetic Modelling.
Drugs R D
December 2024
Galapagos SASU, Romainville, France.
Background And Objective: This study provides a physiologically based pharmacokinetic (PBPK) model-based analysis of the potential drug-drug interaction (DDI) between cyclosporin A (CsA), a breast cancer resistance protein transporter (BCRP) inhibitor, and methotrexate (MTX), a putative BCRP substrate.
Methods: PBPK models for CsA and MTX were built using open-source tools and published data for both model building and for model verification and validation. The MTX and CsA PBPK models were evaluated for their application in simulating BCRP-related DDIs.
Health Care Financing Practices Among U.S. Amish.
J Community Health
December 2024
Division of Genetics, Metabolism, and Genomic Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
The Amish are a rapidly growing Christian ethnoreligious group located in the U.S. and Canada.
View Article and Find Full Text PDF[Predatory journals and paper mills jeopardise knowledge management].
Bull Cancer
December 2024
123, rue Duguesclin, 69006 Lyon, France. Electronic address:
With the advent of the author-pays business model replacing subscription, mercantile publishers have created journals. They respond to the dissatisfaction of naive researchers faced with the difficulties of publishing quickly and widely. These publishers favour commercial interests over knowledge and do not respect good publication practices.
View Article and Find Full Text PDFEvaluating multiple sclerosis severity loci 30 years after a clinically isolated syndrome.
Brain Commun
December 2024
NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, University College London Queen Square Institute of Neurology, London WC1N 3BG, UK.
The first genome-wide significant multiple sclerosis severity locus, rs10191329, has been pathologically linked to cortical lesion load and brain atrophy. However, observational cohorts such as MSBase have not replicated associations with disability outcomes, instead finding other loci. We evaluated rs10191329 and MSBase loci in a unique cohort of 53 people followed for 30 years after a clinically isolated syndrome, with deep clinical phenotyping and MRI measures of inflammation and neurodegeneration.
View Article and Find Full Text PDFPaying to publish: A cross-sectional analysis of article processing charges and journal characteristics among 87 pathology journals.
Acad Pathol
November 2024
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Article processing charges are increasingly being levied on authors via publication fees to provide open access to readers. These charges may impose challenges to early career physicians seeking to publish research but pathology journal article processing charges have not been investigated to date. We aimed to quantify pathology journal article processing charges and investigate the potential associated factors.
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