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Plasma volume response patterns and a physiologic model of ultrafiltration in hemodialysis.
Artif Organs
February 2025
Manchester Academy of Health Sciences Centre, Manchester University Hospitals, Manchester, UK.
Background: Ultrafiltration (UF) is an essential process of restoring fluid homeostasis during hemodialysis (HD). Fluid shifts across the extracellular compartments during UF, predominantly across the capillary interface and between the macro- and microcirculation. A mismatch between UF and transcapillary fluid transport can lead to hemodynamic instability leading to cardiac morbidity.
View Article and Find Full Text PDFThis microfluidic-optical fiber sensor is an experimental system designed to transport and monitor 3D cell cultures, facilitating medical research and technology. This system includes a photonic crystal fiber with a hollow core diameter of 22 µm, which functions as a bridge between two microfluidic devices. The purpose of this system was to transport 3T3 cells (of diameters from 15 µm to 23 µm) between the two devices.
View Article and Find Full Text PDFMathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas.
PLoS Comput Biol
February 2024
Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Physiological abnormalities in pulmonary granulomas-pathological hallmarks of tuberculosis (TB)-compromise the transport of oxygen, nutrients, and drugs. In prior studies, we demonstrated mathematically and experimentally that hypoxia and necrosis emerge in the granuloma microenvironment (GME) as a direct result of limited oxygen availability. Building on our initial model of avascular oxygen diffusion, here we explore additional aspects of oxygen transport, including the roles of granuloma vasculature, transcapillary transport, plasma dilution, and interstitial convection, followed by cellular metabolism.
View Article and Find Full Text PDFRole of the interstitium during septic shock: a key to the understanding of fluid dynamics?
J Intensive Care
October 2023
Médecine Intensive et Réanimation, CHU François Mitterrand, 14 Rue Paul Gaffarel, 21000, Dijon, France.
Background: While not traditionally included in the conceptual understanding of circulation, the interstitium plays a critical role in maintaining fluid homeostasis. Fluid balance regulation is a critical aspect of septic shock, with a well-known association between fluid balance and outcome. The regulation of transcapillary flow is the first key to understand fluid homeostasis during sepsis.
View Article and Find Full Text PDFRecruitment of efferent lymph during infusion of 20 % albumin.
Microvasc Res
July 2023
Karolinska Institutet at Danderyd Hospital (KIDS), Stockholm, Sweden. Electronic address:
Background: Intravenous infusion of hyper-oncotic 20 % albumin expands the plasma volume by approximately twice the infused volume. We investigated whether the recruited fluid stems from accelerated flow of efferent lymph, which would add protein to the plasma, or from reversed transcapillary solvent filtration, where the solvent is expected to be low in protein.
Methods: We analyzed data from 27 intravenous infusions of 20 % albumin (3 mL/kg; approximately 200 mL) over 30 min given to 27 volunteers and patients.
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