Scintigraphy following intravenous administration of 0.1% solution of 11-(ortho-iodine-131-benzoylamino) undecoic acid to rabbits in experimental cholestasis has shown that the intensity of beta-oxidation of this fatty acid in the liver decreases on the 2nd day of cholestasis. Its biological half-life in the liver significantly increases, at an average, 1.75-fold. On the 3rd day this value changes almost 3 times. The extraction of the acid by the liver changes from the first day of cholestasis. Disturbance of renal function from the 2nd day of cholestasis has been also noted. At the same time no significant differences in the time course of changes in the content of 131I-rose bengal have been detected in 1 and 7 days of cholestasis up to the death of part of the animals. The data obtained indicate a possibility of employing the radionuclide method of investigation of change in the intensity of beta-oxidation of fatty acids with the help of the above compound to assess a degree of hepatocytic affection in cholestasis.
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