AI Article Synopsis
- The study evaluated the effectiveness of confocal laser scanning microscopy (CLSM) for real-time examination of laryngeal lesion samples in patients undergoing endoscopic surgery.
- Eight patients with suspected laryngeal lesions had their samples classified as adequate or inadequate based on CLSM findings, with all results later confirmed through histopathology.
- The study concluded that CLSM provides reliable and accurate assessments for larynx pathology, showing good agreement with definitive histological results.
Article Abstract
We aimed to assess the feasibility of using confocal laser scanning microscopy (CLSM) for the real-time ex vivo examination of histological samples of laryngeal lesions and to evaluate the correlation between CLSM and definitive histological results. This preliminary study included eight consecutive patients with "suspected" laryngeal lesions who were candidates for endoscopic laryngeal surgery. The obtained samples were evaluated using CLSM and classified as "inadequate" or "adequate" (high- and low-grade dysplasia, in situ and invasive carcinoma, positive surgical margin, and inflammatory outbreaks). CLSM showed the macro image in all cases and generated a digital version. All the samples were defined as adequate during CLSM and confirmed at histopathology: low-grade dysplasia ( = 5), low- and high-grade dysplasia ( = 2), and high-grade dysplasia ( = 1). Four samples had an involved resection margin, and three samples revealed the presence of inflammatory outbreaks. CLSM can be applied to larynx pathology with excellent agreement with final histological results.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455566 | PMC |
| http://dx.doi.org/10.3390/jpm13081252 | DOI Listing |
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