The relevance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF8 in the pathogenesis of COVID-19 is unclear. Virus natural isolates with deletions in ORF8 were associated with wild milder disease, suggesting that ORF8 might contribute to SARS-CoV-2 virulence. This manuscript shows that ORF8 is involved in inflammation and in the activation of macrophages in two experimental systems: humanized K18-hACE2 transgenic mice and organoid-derived human airway cells. These results identify ORF8 protein as a potential target for COVID-19 therapies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653805 | PMC |
| http://dx.doi.org/10.1128/mbio.00451-23 | DOI Listing |
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- SARS-CoV-2, the virus responsible for COVID-19, has caused millions of deaths, highlighting the need to understand its emergence and how it spills over to humans.
- A study analyzed recombination among coronaviruses, identifying 199 events with a majority occurring within species rather than between them, and found that these genomic changes predominantly affect specific regions of the virus's genome.
- The research concluded that SARS-CoV-2 likely gained its unique features through recombination with related viruses in the same species, emphasizing the importance of understanding these processes to prevent future outbreaks.
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